Stressor: 11
Title
Bis(2-ethylhexyl) phthalate
Stressor Overview
AOPs Including This Stressor
Events Including This Stressor
Chemical Table
User term | DTXID | Preferred name | Casrn | jchem_inchi_key | indigo_inchi_key |
---|---|---|---|---|---|
bis(2-ethylhexyl) phthalate | DTXSID5020607 | Di(2-ethylhexyl) phthalate | 117-81-7 | BJQHLKABXJIVAM-UHFFFAOYNA-N | BJQHLKABXJIVAM-UHFFFAOYSA-N |
AOP Evidence
PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
There is no evidence text for this AOP
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
There is no evidence text for this AOP
Event Evidence
Activation, PPARα & PPARγ
There is no evidence text for this event.
Decreased, plasma 11-ketotestosterone level
A review of androgen signaling in fish cites several studies showing DEHP decreased 11KT (Golshan et al., 2019)
Impaired, Spermatogenesis
A review of androgen signaling in male fish cites several studies showing DEHP decreases sperm quality (Golshan et al., 2019)
decrease, male anogenital distance
DEHP has been shown to cause decreased male AGD in rats following intrauterine exposure to 300-1500 mg/kg bw/day (Christiansen et al, 2010; Gray et al, 2000; Howdeshell et al, 2007; Jarfelt et al, 2005; Kita et al, 2016; Li et al, 2013; Lin et al, 2009; Moore et al, 2001; Nardelli et al, 2017; Saillenfait et al, 2009; Wolf et al, 1999).
Disrupted meiotic initiation of fetal oogonia of the ovary
Diethyl hexyl phthalate (DEHP) exposure at a dose of 40 mg kg-1 from E0.5 to E18.5, caused delayed meiosis of oocytes, evident by delayed Stra8 expression and meiotic progression determined by SYCP3 staining of chromosome spreads (Zhang et al, 2015). An in vitro model reported the same delay to meiosis when E12.5 ovaries were cultured in 10 µM and 100 µM concentrations of DEHP (Liu et al, 2017).
Decrease (loss of) fetal male germ cells
Di(2-ethylhexyl) phthalate (DEHP) exposure induces apoptosis to gonocytes in rat testis after intrauterine exposure to 500 and 750 mg/kg bw/day (Ryu et al, 2007).