Stressor: 43

Title

Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help

Organophosphates

Stressor Overview

A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help

AOPs Including This Stressor

This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help

AOP Name	Evidence
Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function	High
Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality	High
Increased glutamate leads to economic burden through reduced IQ and non-cholinergic mechanisms

Chemical Table

A list of chemicals associated with a prototypical stressor. More help

Preferred name	DTXID	Casrn	jchem_inchi_key	indigo_inchi_key	User term
Parathion	DTXSID7021100	56-38-2	LCCNCVORNKJIRZ-UHFFFAOYSA-N	LCCNCVORNKJIRZ-UHFFFAOYSA-N	parathion
Pinacolyl methylphosphonofluoridate	DTXSID2031906	96-64-0	GRXKLBBBQUKJJZ-UHFFFAOYNA-N	GRXKLBBBQUKJJZ-UHFFFAOYSA-N	Pinacolyl methylfluorophosphonate

References

List of the literature that was cited for this prototypical stressor. More help

Collombet JM, Four E, Fauquette W, Burckhart MF, Masqueliez C, Bernabe D, Baubichon D, Lallement G (2007) Soman poisoning induces delayed astrogliotic scar and angiogenesis in damaged mouse brain areas. Neurotoxicology 28: 38-48

Zurich MG, Honegger P, Schilter B, Costa LG, Monnet-Tschudi F (2004) Involvement of glial cells in the neurotoxicity of parathion and chlorpyrifos. Toxicol Appl Pharmacol 201: 97-104