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AOP: 394
Title
SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
Short name
Graphical Representation
Point of Contact
Contributors
- Magda Sachana
- Francesca De Bernardi
- Sandra Coecke
- Laure-Alix Clerbaux
- Arthur Author
Coaches
- Cinzia La Rocca
OECD Information Table
OECD Project # | OECD Status | Reviewer's Reports | Journal-format Article | OECD iLibrary Published Version |
---|---|---|---|---|
1.96 | Under Development |
This AOP was last modified on May 26, 2024 20:39
Revision dates for related pages
Page | Revision Date/Time |
---|---|
Binding to ACE2 | August 30, 2023 20:36 |
SARS-CoV-2 cell entry | April 04, 2023 07:39 |
Sustentacular cells, decrease | March 30, 2022 11:11 |
olfactory sensory neurons, decrease | March 30, 2022 11:22 |
Olfactory epithelium degeneration | March 30, 2022 11:24 |
impaired olfactory function (anosmia) | March 30, 2022 11:26 |
Increased SARS-CoV-2 production | June 14, 2022 08:49 |
Binding to ACE2 leads to SARS-CoV-2 cell entry | February 07, 2023 23:24 |
Sustentacular cells, decrease leads to anosmia | April 26, 2021 14:52 |
olfacotry neurons, decrease leads to anosmia | April 26, 2021 14:53 |
SARS-CoV-2 cell entry leads to SARS-CoV-2 production | February 07, 2023 23:23 |
SARS-CoV-2 production leads to Sustentacular cells, decrease | January 05, 2022 08:20 |
Sustentacular cells, decrease leads to olfacotry neurons, decrease | April 26, 2021 14:51 |
olfacotry neurons, decrease leads to Olfactory epithelium degeneration | April 26, 2021 14:51 |
Olfactory epithelium degeneration leads to anosmia | April 26, 2021 14:52 |
Abstract
AOP Development Strategy
Context
AOP394 is developed as a part of the CIAO project, "Modelling the Pathogenesis of COVID-19 Using the Adverse Outcome Pathway (AOP)". The overall goal is to organize and understand the vast amount of data that is constantly evolving as a result of the COVID-19 pandemic and identify uncertainties and knowledge gaps that may be missing using the AOP framework. Many AOPs were developed in the CIAO project, each AOP focusing on a specific element of the SARS-COV-2 virus responses in humans.
AOP394 focuses on the short-term olfactory disfunction (anosmia) following binding of SARS-CoV-2 to ACE2 receptors in the sustencular cells of the olfactory epithelium.
Strategy
Summary of the AOP
Events:
Molecular Initiating Events (MIE)
Key Events (KE)
Adverse Outcomes (AO)
Type | Event ID | Title | Short name |
---|
MIE | 1739 | Binding to ACE2 | Binding to ACE2 |
KE | 1738 | SARS-CoV-2 cell entry | SARS-CoV-2 cell entry |
KE | 1847 | Increased SARS-CoV-2 production | SARS-CoV-2 production |
KE | 1870 | Sustentacular cells, decrease | Sustentacular cells, decrease |
KE | 1871 | olfactory sensory neurons, decrease | olfacotry neurons, decrease |
KE | 1872 | Olfactory epithelium degeneration | Olfactory epithelium degeneration |
AO | 1873 | impaired olfactory function (anosmia) | anosmia |
Relationships Between Two Key Events (Including MIEs and AOs)
Title | Adjacency | Evidence | Quantitative Understanding |
---|
Sustentacular cells, decrease leads to anosmia | non-adjacent | ||
olfacotry neurons, decrease leads to anosmia | non-adjacent |