AOPs

OECD View API
Toggle for API info
The API endpoint defaults to 25 results per page, but you can adjust this by changing the per_page parameter in the URL.
Searches both title and fulltext content
Takes you to the requested AOP
Clear Search Terms Clears search terms and filters

Showing 426 to 450 of 476 AOPs

Clear Table Filters
ID Title Point of Contact License MIE AO OECD Status OECD Project
486 Binding to the extracellular protein laminin leading to decreased cognitive function Allie Always BY-SA 2109: Binding, extracellular matrix protein laminin 402: Cognitive Function, Decreased
487 Unknown MIE altering cholesterol metabolism leading to decreased cognition Evgeniia Kazymova BY-SA 1114: Unknown, MIE 402: Cognitive Function, Decreased
488 Increased reactive oxygen species production leading to decreased cognitive function Cataia Ives BY-SA 257: Increase, Reactive Oxygen Species production 402: Cognitive Function, Decreased
489 Inhibition of voltage-gated sodium channels leading to decreased cognition Brendan Ferreri-Hanberry BY-SA 1353: Binding to voltage-gated sodium channel 402: Cognitive Function, Decreased
490 Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms Arthur Author BY-SA
491 Decrease, GLI1/2 target gene expression leads to orofacial clefting Agnes Aggy BY-SA 2040: Decrease, GLI1/2 target gene expression 2042: Orofacial clefting Under Development 1.101
492 Glutathione conjugation leading to reproductive dysfunction via oxidative stress Allie Always BY-SA 2131: Conjugation, GSH 406: impaired, Fertility
493 ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity Evgeniia Kazymova BY-SA 2126: Estrogen receptor alpha inactivation 2129: Metabolically unhealthy Obesity
494 AhR activation leading to liver fibrosis Cataia Ives BY-SA 18: Activation, AhR 344: N/A, Liver fibrosis
495 Androgen receptor activation leading to prostate cancer Brendan Ferreri-Hanberry BY-SA 785: Activation, Androgen receptor 2135: Prostate cancer
496 Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） Arthur Author BY-SA 442: Decreased, Population trajectory
497 ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome Agnes Aggy BY-SA 2126: Estrogen receptor alpha inactivation
498 Increased LCN2/iron complex leading to neurological disorders Allie Always Open for adoption 2148: Increased LCN2/iron complex binds to SLC22A17 receptor in neuron 2150: Neurological disorder
499 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release Evgeniia Kazymova BY-SA 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 341: Impairment, Learning and memory
500 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis Cataia Ives BY-SA 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 341: Impairment, Learning and memory
501 Excessive iron accumulation leading to neurological disorders Brendan Ferreri-Hanberry Open for adoption 2149: Increased intracelluar Iron accumulation 2150: Neurological disorder
502 Decrease, cholesterol synthesis leads to orofacial clefting Arthur Author BY-SA None 2042: Orofacial clefting Under Development 1.101
503 Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation Agnes Aggy BY-SA 1065: Activation, estrogen receptor alpha 2154: Uterine adenocarcinoma (endometrioid adenocarcinoma Type I)
504 SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level Allie Always BY-SA 2155: Inhibition of Sulfotransferase E1 (SULT1E1) None
505 Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway Evgeniia Kazymova BY-SA 1115: Increased, Reactive oxygen species 885: Increase, Cancer
506 Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation Cataia Ives BY-SA 2158: Influenza A Virus (IAV) binds sialic acid glycan receptor 2194: Influenza A Virus (IAV) shedding and transmission
507 Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway Brendan Ferreri-Hanberry BY-SA 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
508 Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway Arthur Author BY-SA 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
509 Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction Agnes Aggy BY-SA 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
510 Demethylation of PPAR promotor leading to vascular disrupting effects Allie Always BY-SA 228: peroxisome proliferator activated receptor promoter demethylation 2161: Increase, Vascular disrupting effects