All AOPs With SAAOP Status Recent AOPs

AOPs With OECD Status

TFHA/WNT Endorsed

Open for citation & comment

Title Point of Contact MIE AO OECD Project
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Evgeniia Kazymova DNA alkylation heritable mutations 1.11
Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Evgeniia Kazymova AR reproductive dysfunction 1.12
Antagonist binding to PPARα leading to body-weight loss Agnes Aggy PPAR starvation-like body-weight loss 2.3
Aromatase inhibition leading to reproductive dysfunction Cataia Ives Aromatate Inhib reproductive dysfunction 1.12
Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Allie Always AhR embryo toxicity 1.27
Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Arthur Author Activation, AhR Increase, Early Life Stage Mortality 1.7
Aryl hydrocarbon receptor activation leading to uroporphyria Allie Always AhR uroporphyria 1.7
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Allie Always Glutamate Receptor learning and memory impairment. 1.23
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Cataia Ives GABA epileptic seizures 1.15
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Agnes Aggy NMDAR impairment of learning and memory abilities 1.22
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Arthur Author NMDAR neuroinflammation and lead to neurodegeneration 1.13
Covalent Protein binding leading to Skin Sensitisation Agnes Aggy Covalent Binding, Protein sensitisation, skin 1.1
Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Arthur Author NIS learning and memory deficits in children 1.28
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Cataia Ives NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor Motor function, impaired 1.33
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova TPO neurodevelopmental outcomes 1.10
Protein Alkylation leading to Liver Fibrosis Brendan Ferreri-Hanberry Protein alkylation liver fibrosis 1.14

EAGMST Under Review

Open for citation & comment

Title Point of Contact MIE AO OECD Project
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Agnes Aggy AFB1 hepatocellular carcinoma 1.8
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Allie Always PPAR impaired fertility 1.21
Chemical binding to tubulin in oocytes leading to aneuploid offspring Cataia Ives tubulin? aneuploid offspring 1.11
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Brendan Ferreri-Hanberry CAR hepatocellular adenomas and carcinomas 1.17
Cyp2E1 Activation Leading to Liver Cancer Agnes Aggy Activation of Cyp2E1 liver cancer 1.24
Disruption of VEGFR Signaling Leading to Developmental Defects Cataia Ives VEGF developmental outcomes 1.6
Estrogen receptor antagonism leading to reproductive dysfunction Evgeniia Kazymova ER reproductive dysfunction 1.12
Histone deacetylase inhibition leading to testicular atrophy Brendan Ferreri-Hanberry Histone deacetylase, inhibition testicular toxicity 1.52
Impaired IL-1R1 signaling leading to increased susceptibility to infection Cataia Ives 1.48
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Cataia Ives unclear contact nasal tumors 2.7
PPARα activation in utero leading to impaired fertility in males Arthur Author PPAR impaired fertility 1.21
Sustained AhR Activation leading to Rodent Liver Tumours Allie Always AhR liver tumors 1.7

Open for comment. Do not cite

Title Point of Contact MIE AO OECD Project
Inhibitor binding to topoisomerase II leading to infant leukaemia Agnes Aggy 1.53
Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Cataia Ives Calcineurin Activity, Inhibition 1.38
Oxidative DNA damage leading to chromosomal aberrations and mutations Brendan Ferreri-Hanberry 1.76

Open for adoption

Title Point of Contact MIE AO OECD Project
Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation Allie Always 1.35
Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation Agnes Aggy 1.35
Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Arthur Author 1.35
Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation Brendan Ferreri-Hanberry 1.35
Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Evgeniia Kazymova 1.35

Under development: Not open for comment. Do not cite

Title Point of Contact MIE AO OECD Project
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Brendan Ferreri-Hanberry multiple neuroinflammation leading to neurodegeneration 1.13
Direct deposition of ionizing energy leading to lung cancer Brendan Ferreri-Hanberry 1.56
Endocytic lysosomal uptake leading to liver fibrosis Allie Always Liver, Inflammation 1.47
Reactive oxygen species generated from photoreactive chemicals leading to phototoxic reactions Evgeniia Kazymova 1.49
Substance interaction with the lung resident cell membrane components leading to lung fibrosis Cataia Ives 1.32

Under Development: Contributions and Comments Welcome

Title Point of Contact MIE AO OECD Project
Chronic reactive oxygen species leading to human treatment-resistant gastric cancer Agnes Aggy 1.58

Under Development

Open for citation & comment

Title Point of Contact MIE AO OECD Project
Inhibition of 5α-reductase leading to impaired fecundity in female fish Cataia Ives 1.81
Inhibition of tyrosinase leads to decreased population in fish Agnes Aggy 1.78

Open for comment. Do not cite

Title Point of Contact MIE AO OECD Project
Inhibition of thyroid peroxidase leading to impaired fertility in fish Cataia Ives 1.59
Uncoupling of oxidative phosphorylation leading to growth inhibition (1) Allie Always 1.92

Open for adoption

Title Point of Contact MIE AO OECD Project
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Evgeniia Kazymova AR adenomas and carcinomas 1.26
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Allie Always Transthyretin 1.41
Oxidation of iron in hemoglobin leading to hematotoxicity Cataia Ives heme oxidation ? hematotoxicity 1.16

Not under active development

Title Point of Contact MIE AO OECD Project
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Brendan Ferreri-Hanberry 1.31
Peptide Oxidation Leading to Hypertension Brendan Ferreri-Hanberry 1.50
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Brendan Ferreri-Hanberry case study 2.5
PPARα activation leading to impaired fertility in adult male rodents Evgeniia Kazymova PPAR α impaired fertility 1.21
Renal protein alkylation leading to kidney toxicity Evgeniia Kazymova 1.43
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova mulitple neurodevelopmental outcomes 1.9

Under development: Not open for comment. Do not cite

Title Point of Contact MIE AO OECD Project
5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Allie Always 1.90
AhR activation leading to preeclampsia Agnes Aggy 1.42
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Evgeniia Kazymova 1.90
Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Cataia Ives 1.73
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Arthur Author ABCB11 cholestatic liver injury 1.19
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Cataia Ives 1.90
Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Cataia Ives 1.79
EGFR Activation Leading to Decreased Lung Function Cataia Ives EGFR 1.51
Frustrated phagocytosis-induced lung cancer Arthur Author 1.86
Increased DNA damage leading to increased risk of breast cancer Allie Always 1.80
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Evgeniia Kazymova 1.80
Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Brendan Ferreri-Hanberry 1.74
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Agnes Aggy 1.43
Kidney dysfunction by decreased thyroid hormone Arthur Author unclear - KE as MIE? kidnney dysfunction 1.40
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Arthur Author 1.45
L-type calcium channel blockade leading to hypotension Cataia Ives 1.45
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Agnes Aggy 1.45
Lung surfactant function inhibition leading to impaired lung function Brendan Ferreri-Hanberry 1.87
Narcosis leading to respiratory failure Allie Always undefined sensitisation of the respiratory tract 1.2
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Brendan Ferreri-Hanberry 1.54
PPARα activation leading to hepatocellular adenomas and carcinomas in rodents Cataia Ives PPAR alpha liver cancer 1.17
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Allie Always 1.43
Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Arthur Author 1.55
Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Evgeniia Kazymova 1.75
Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Thyroid Receptor Antagonism Cognitve function, Decreased 1.84
Trypsin inhibition leading to pancreatic acinar cell tumors Arthur Author 1.60
Uncoupling of oxidative phosphorylation leading to growth inhibition (2) Evgeniia Kazymova 1.92
Uncoupling of oxidative phosphorylation leading to growth inhibition (3) Cataia Ives 1.92
Uncoupling of oxidative phosphorylation leading to growth inhibition (4) Brendan Ferreri-Hanberry 1.92
Uncoupling of oxidative phosphorylation leading to growth inhibition (5) Arthur Author 1.92
Uncoupling of oxidative phosphorylation leading to growth inhibition (6) Agnes Aggy 1.92

Under Development: Contributions and Comments Welcome

Title Point of Contact MIE AO OECD Project
Acetylcholinesterase inhibition leading to acute mortality Cataia Ives AChE acute mortality 1.3
Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins leads to Sensitisation (Sensitization) of the Respiratory Tract Arthur Author unclear what proteins sensitisation of the respiratory tract 1.20
Inhibition of retinaldehyde dehydrogenase leads to population decline Arthur Author 1.77
Phospholipase A inhibitors lead to hepatotoxicity Agnes Aggy phospolipase A hepatotoxicity 1.39