5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring |
Allie Always |
|
- decrease, male anogenital distance
|
1.90 |
AhR activation leading to preeclampsia |
Agnes Aggy |
|
|
1.42 |
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring |
Evgeniia Kazymova |
- Antagonism, Androgen receptor
|
- decrease, male anogenital distance
|
1.90 |
Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis |
Allie Always |
- Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
|
|
1.96 |
Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis |
Cataia Ives |
|
|
1.96 |
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis |
Agnes Aggy |
|
|
1.96 |
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) |
Agnes Aggy |
|
- Cerebrovascular disease (stroke)
|
1.96 |
Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption |
Cataia Ives |
|
|
1.96 |
Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation |
Arthur Author |
|
- Viral infection and host-to-host transmission, proliferated
|
1.96 |
Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia |
Agnes Aggy |
|
|
1.96 |
Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation |
Arthur Author |
- Binding to ACE2
- SARS-CoV-2 cell entry
- Increased SARS-CoV-2 production
|
- Thrombosis and Disseminated Intravascular Coagulation
|
1.96 |
Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) |
Cataia Ives |
- Binding to estrogen receptor (ER)-α in immune cells
|
- Exacerbation of systemic lupus erythematosus (SLE)
|
1.73 |
Bulky DNA adducts leading to mutations |
Evgeniia Kazymova |
- Bulky DNA adducts, increase
|
|
1.11 |
Chitinase inhibition leading to mortality |
Evgeniia Kazymova |
|
|
1.94 |
Chitobiase inhibition leading to mortality |
Cataia Ives |
|
|
1.94 |
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) |
Arthur Author |
- Inhibition, Bile Salt Export Pump (ABCB11)
|
|
1.19 |
Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation |
Cataia Ives |
- Fibrinolysis, decreased
- Bradykinin system, hyperactivated
|
|
1.96 |
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring |
Cataia Ives |
|
- decrease, male anogenital distance
|
1.90 |
Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk |
Cataia Ives |
|
|
1.79 |
EGFR Activation Leading to Decreased Lung Function |
Cataia Ives |
|
|
1.51 |
Endothelial cell dysfunction leading to thromboinflammation |
Arthur Author |
|
- Thromboinflammation, Increased
|
1.96 |
Frustrated phagocytosis-induced lung cancer |
Arthur Author |
|
|
1.86 |
Increased DNA damage leading to increased risk of breast cancer |
Allie Always |
|
- Increase, Mutations
- Increased, Ductal Hyperplasia
- N/A, Breast Cancer
|
1.80 |
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer |
Evgeniia Kazymova |
- Increase in reactive oxygen and nitrogen species (RONS)
|
- Increase, DNA damage
- Increase, Mutations
- Increased, Ductal Hyperplasia
- N/A, Breast Cancer
|
1.80 |
Inhibition of 11β-hydroxylase leading to decresed population trajectory |
Allie Always |
- 11β-hydroxylase inhibition
|
- Decrease, Population growth rate
|
1.93 |
Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory |
Agnes Aggy |
|
- Decrease, Population growth rate
|
1.93 |
Inhibition of ALDH1A (RALDH) causing reduced all-trans retinoic acid levels leading to impaired fertility, females |
Cataia Ives |
- Inhibition of ALDH1A (RALDH)
|
|
1.97 |
Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis |
Evgeniia Kazymova |
- Induced dysregulation of ACE2
|
|
1.96 |
Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response |
Brendan Ferreri-Hanberry |
|
- Impairment of T-cell dependent antibody response
|
1.74 |
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity |
Agnes Aggy |
- Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)
|
- Occurrence, Kidney toxicity
|
1.43 |
Kidney dysfunction by decreased thyroid hormone |
Arthur Author |
- Thyroid hormone synthesis, Decreased
|
- Occurrence, Kidney toxicity
|
1.40 |
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility |
Arthur Author |
- Blockade, L-Type Calcium Channels
|
|
1.45 |
L-type calcium channel blockade leading to hypotension |
Cataia Ives |
|
|
1.45 |
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology |
Agnes Aggy |
|
|
1.45 |
Narcosis leading to respiratory failure |
Allie Always |
- Accumulation, Biological membranes
|
|
1.2 |
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis |
Brendan Ferreri-Hanberry |
|
|
1.54 |
PPARα activation leading to hepatocellular adenomas and carcinomas in rodents |
Cataia Ives |
|
- Increase, hepatocellular adenomas and carcinomas
|
1.17 |
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity |
Allie Always |
- Binding of substrate, endocytic receptor
|
- Occurrence, Kidney toxicity
|
1.43 |
SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) |
Arthur Author |
|
- impaired olfactory function (anosmia)
|
1.96 |
Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression |
Arthur Author |
- Sensing of the stressor by pulmonary cells
|
- Plaque progression in arteries
|
1.55 |
Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease |
Evgeniia Kazymova |
|
|
1.75 |
Sulfonylureareceptor binding leading to mortality |
Arthur Author |
- Increase, Sulfonylurea receptor binding
|
|
1.94 |
Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Evgeniia Kazymova |
- Antagonism, Thyroid Receptor
|
- Cognitive Function, Decreased
|
1.84 |
Trypsin inhibition leading to pancreatic acinar cell tumors |
Arthur Author |
|
- Pancreatic acinar cell tumors
|
1.60 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased lipid storage |
Cataia Ives |
- Decrease, Coupling of oxidative phosphorylation
|
|
1.92 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via increased lipid peroxidation |
Arthur Author |
- Decrease, Coupling of oxidative phosphorylation
|
|
1.92 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via increased protein oxidation |
Agnes Aggy |
- Decrease, Coupling of oxidative phosphorylation
|
|
1.92 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via oxidative DNA damage |
Brendan Ferreri-Hanberry |
- Decrease, Coupling of oxidative phosphorylation
|
|
1.92 |