AOP-Wiki

API

All Key Events

Showing 301 to 325 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

601	Overactivation, muscle contraction Short Name Overactivation, muscle contraction	1	Tissue	Nov 29, 2016	Sep 16, 2017	96: Axonal sodium channel modulation leading to acute mortality
602	Increased, Ataxia, paralysis, or hyperactivity Short Name	3	Organ	Nov 29, 2016	Sep 16, 2017	96: Axonal sodium channel modulation leading to acute mortality
613	Occurrence, Epileptic seizure Short Name Occurrence, Epileptic seizure	1	Individual	Nov 29, 2016	Apr 29, 2019	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
616	Occurrence, A paroxysmal depolarizing shift Short Name	1	Tissue	Nov 29, 2016	Apr 29, 2019	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
618	Decreased, Neuronal network function in adult brain Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	3 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 471: Various neuronal effects induced by elavl3, sox10, and mbp
619	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Short Name	2	Molecular	Nov 29, 2016	Sep 16, 2017	5 AOPs 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
620	Increased, serotonin (5-HT) 1 1 Short Name Increased, serotonin (5-HT) 1	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
621	Increase, cilia movement Short Name Increase, cilia movement	0	Tissue	Nov 29, 2016	Jan 13, 2017	3 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
622	Increased, locomotion Short Name Increased, locomotion	1	Individual	Nov 29, 2016	Dec 3, 2016	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
623	Increase, predation Short Name Increase, predation	1	Population	Nov 29, 2016	Dec 3, 2016	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
624	Increased, foot detachment Short Name Increased, foot detachment	1	Individual	Nov 29, 2016	Dec 3, 2016	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
625	Increased, muscular waves in foot Short Name Increased, muscular waves in foot	0	Organ	Nov 29, 2016	Sep 16, 2017	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
626	Increased, serotonin (5-HT) Short Name Increased, serotonin (5-HT)	1	Cellular	Nov 29, 2016	Sep 16, 2017	5 AOPs 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
627	Decreased, anxiety Short Name Decreased, anxiety	1	Individual	Nov 29, 2016	Dec 3, 2016	98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
629	Decreased, sheltering Short Name Decreased, sheltering	1	Individual	Nov 29, 2016	Dec 3, 2016	98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
633	Decrease, histaminergic neuron excitation Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	99: Histamine (H2) receptor antagonism leading to reduced survival
634	N/A, sedation Short Name N/A, sedation	1	Individual	Nov 29, 2016	Dec 3, 2016	99: Histamine (H2) receptor antagonism leading to reduced survival
635	Decreased, locomotion Short Name Decreased, locomotion	1	Individual	Nov 29, 2016	Dec 3, 2016	99: Histamine (H2) receptor antagonism leading to reduced survival
636	Decreased, survival Short Name Decreased, survival	1	Population	Nov 29, 2016	Dec 3, 2016	2 AOPs 99: Histamine (H2) receptor antagonism leading to reduced survival 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
637	impaired, Learning and memory Short Name impaired, Learning and memory	0	Individual	Nov 29, 2016	Dec 3, 2016	471: Various neuronal effects induced by elavl3, sox10, and mbp
638	Antagonism, Histamine Receptor (H2) Short Name Antagonism, Histamine Receptor (H2)	1	Molecular	Nov 29, 2016	Sep 16, 2017	99: Histamine (H2) receptor antagonism leading to reduced survival
640	Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	70: Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
642	Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	69: Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
643	Decreased Cholesterol, Decreased Uptake of Lipoproteins Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	69: Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
644	Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	69: Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell