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All Key Events

Showing 376 to 400 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

716	Increase, cell proliferation (hepatocytes) Short Name	2	Cellular	Nov 29, 2016	Jan 6, 2021	3 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
718	Binding, Tubulin Short Name Binding, Tubulin	2	Molecular	Nov 29, 2016	Apr 20, 2021	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
719	Increase, hepatocellular adenomas and carcinomas Short Name	3	Tissue	Nov 29, 2016	Dec 26, 2020	5 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
720	Disruption, Microtubule dynamics Short Name Disruption, Microtubule dynamics	1	Molecular	Nov 29, 2016	Nov 7, 2019	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
721	Disorganization, Meiotic Spindle Short Name Disorganization, Meiotic Spindle	1	Cellular	Nov 29, 2016	Apr 20, 2021	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
723	Altered, Chromosome number Short Name Altered, Chromosome number	1	Cellular	Nov 29, 2016	May 27, 2019	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
724	Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
726	Increased, Induction of pyruvate dehydrogenase (PDH) Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
728	Increase, Aneuploid offspring Short Name Increase, Aneuploid offspring	1	Individual	Nov 29, 2016	May 27, 2019	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
733	Increase, Necrosis (terminal bronchiolar cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
734	Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
735	Increase, Hyperplasia (terminal bronchiolar cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
736	Increase, Adenomas/carcinomas (bronchioloalveolar) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
737	Decreased, Uptake of inorganic iodide Short Name Decreased, Uptake of inorganic iodide	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
739	Increase, Hypertrophy and proliferation (follicular cell) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
740	Increase, Hyperplasia (follicular cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
741	Increase, Adenomas/carcinomas (follicular cell) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
742	Decreased, Androgen receptor activity Short Name Decreased, Androgen receptor activity	1	Molecular	Nov 29, 2016	Dec 3, 2016	111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
743	Decreased, Testosterone binding to androgen receptor (hypothalamus) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
744	Increase, Hyperplasia (Leydig cells) Short Name Increase, Hyperplasia (Leydig cells)	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
745	Increase, Leydig cell tumors Short Name Increase, Leydig cell tumors	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
746	Increase, Dopaminergic activity Short Name Increase, Dopaminergic activity	1	Cellular	Nov 29, 2016	Sep 16, 2017	112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
747	Decreased, Prolactin Short Name Decreased, Prolactin	1	Tissue	Nov 29, 2016	Sep 16, 2017	112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
748	Increased, Estrogen receptor (ER) activity Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	2 AOPs 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) 465: Alcohol dehydrogenase leading to reproductive dysfunction
749	Decreased, Progesterone from corpus luteum Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)