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All Key Events

Showing 451 to 475 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

805	Decreased, mevalonate Short Name Decreased, mevalonate	1	Cellular	Nov 29, 2016	Dec 3, 2016	124: HMG-CoA reductase inhibition leading to decreased fertility
807	Decreased, cholesterol Short Name Decreased, cholesterol	3	Tissue	Nov 29, 2016	May 24, 2022	2 AOPs 124: HMG-CoA reductase inhibition leading to decreased fertility 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
809	malformed, Male reproductive tract Short Name malformed, Male reproductive tract	1	Individual	Nov 29, 2016	Sep 16, 2017	124: HMG-CoA reductase inhibition leading to decreased fertility
813	Increased, Serum creatinine Short Name Increased, Serum creatinine	2	Organ	Nov 29, 2016	Sep 16, 2017	128: Kidney dysfunction by decreased thyroid hormone
814	Occurrence, Kidney toxicity Short Name Occurrence, Kidney toxicity	1	Organ	Nov 29, 2016	Mar 4, 2022	7 AOPs 128: Kidney dysfunction by decreased thyroid hormone 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 258: Renal protein alkylation leading to kidney toxicity 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
818	Occurrence, Cytoplasmic vacuolization (Renal tubule) Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	128: Kidney dysfunction by decreased thyroid hormone
819	Decreased, Glomerular filtration Short Name Decreased, Glomerular filtration	1	Tissue	Nov 29, 2016	Jun 21, 2024	2 AOPs 128: Kidney dysfunction by decreased thyroid hormone 534: Activation of Protein kinase C leads to Kidney Failure
820	Decreased, Renal plasma flow Short Name Decreased, Renal plasma flow	1	Tissue	Nov 29, 2016	Sep 16, 2017	128: Kidney dysfunction by decreased thyroid hormone
821	Decreased, Sodium reabsorption Short Name Decreased, Sodium reabsorption	1	Organ	Nov 29, 2016	Sep 16, 2017	128: Kidney dysfunction by decreased thyroid hormone
823	Occurrence, Cystic dilatation (renal tubule) Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	128: Kidney dysfunction by decreased thyroid hormone
824	Occurrence, Cytoplasmic vacuolization (podocyte) Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	128: Kidney dysfunction by decreased thyroid hormone
825	Decreased, Renal ability to dilute urine Short Name	1	Organ	Nov 29, 2016	Dec 3, 2016	128: Kidney dysfunction by decreased thyroid hormone
826	Activation, Keratinocytes Short Name Activation, Keratinocytes	2	Cellular	Nov 29, 2016	Sep 16, 2017	40: Covalent Protein binding leading to Skin Sensitisation
827	sensitisation, skin Short Name sensitisation, skin	0	Organ	Nov 29, 2016	Nov 29, 2016	40: Covalent Protein binding leading to Skin Sensitisation
828	Inhibition, Phospholipase A Short Name Inhibition, Phospholipase A	1	Molecular	Nov 29, 2016	Dec 3, 2016	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
829	Damage, Lipid bilayer Short Name Damage, Lipid bilayer	1	Cellular	Nov 29, 2016	Dec 3, 2016	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
831	Disturbance, Lysosomal function Short Name Disturbance, Lysosomal function	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
833	Occurrence, Cytoplasmic vacuolization (hepatocyte) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
835	Occurrence, Ballooning degeneration (hepatocyte) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
836	Occurrence, Cytoplasmic vacuolization (Bile duct cell) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
837	Occurrence, Cytoplasmic vacuolization (kupffer cell) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
838	Induction, Microvesicular fat Short Name Induction, Microvesicular fat	1	Tissue	Nov 29, 2016	Dec 3, 2016	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
839	Formation, Mallory body Short Name Formation, Mallory body	1	Cellular	Nov 29, 2016	Dec 3, 2016	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
840	Formation, Liver fibrosis Short Name Formation, Liver fibrosis	1	Tissue	Nov 29, 2016	Sep 16, 2017	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
844	Oxidation, Uroporphyrinogen Short Name Oxidation, Uroporphyrinogen	1	Cellular	Nov 29, 2016	Sep 16, 2017	131: Aryl hydrocarbon receptor activation leading to uroporphyria