AOP-Wiki

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All Key Events

Showing 901 to 925 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1333	Increase, mental stress Short Name Increase, mental stress	0	Individual	Apr 13, 2017	Apr 13, 2017	None
1334	Increase, cortisone Short Name Increase, cortisone	0	Molecular	Apr 13, 2017	Apr 13, 2017	214: Network of SSRIs (selective serotonin reuptake inhibitors)
1335	Reduced, BDNF (Brain-derived neurotrophic factor) Short Name Reduced, BDNF	0	Molecular	Apr 13, 2017	May 31, 2017	3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation
1336	Activation, 5-HT2A (Serotonin 2A) Short Name Activation, 5-HT2A	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1337	Activate, PLC (Phospholipase C) Short Name Activate, PLC	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1338	Increase, inositol triphosphate Short Name Increase, inositol triphosphate	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1339	Increase, intracellular calcium Short Name Increase, intracellular calcium	1	Cellular	Apr 13, 2017	Jul 21, 2023	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
1340	Activate, calmodulin Short Name Activate, calmodulin	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1341	Increase, myosin light chain phosphorylation Short Name	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1342	Increase, vascular smooth muscle contraction Short Name	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1343	Increase, hypertension Short Name Increase, hypertension	0	Individual	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1344	Increased, seizure Short Name Increased, seizure	0	Individual	Apr 13, 2017	Jun 1, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 223: Serotonin transporter activation to seizure 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1345	Increased, agitation Short Name Increased, agitation	0	Molecular	Apr 13, 2017	Jun 1, 2017	3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 222: Mental stress to agitation 225: Serotonin transporter activation to agitation
1346	Increased, depression Short Name Increased, depression	0	Individual	Apr 13, 2017	Jun 1, 2017	3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 224: Serotonin transporter activation to depression
1347	Decreased, extracellular serotonin Short Name Decreased, extracellular serotonin	0	Molecular	Apr 14, 2017	May 31, 2017	7 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1348	Increase, seizure Short Name Increase, seizure	0	Individual	Apr 14, 2017	Apr 14, 2017	3 AOPs 215: Molecular events lead to epilepsy 402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain 471: Various neuronal effects induced by elavl3, sox10, and mbp
1349	Activated, presynaptic neuron 1 Short Name Activated, presynaptic neuron 1	0	Molecular	Apr 14, 2017	Jun 2, 2017	3 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 471: Various neuronal effects induced by elavl3, sox10, and mbp
1350	Increased, glutamate Short Name Increased, glutamate	1	Molecular	Apr 14, 2017	Oct 11, 2021	4 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 490: Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
1351	Activated, NMDA receptor Short Name Activated, NMDA receptor	0	Molecular	Apr 14, 2017	Jun 2, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
1352	Activated, voltage-gated sodium channel Short Name Activated, voltage-gated sodium channel	0	Molecular	Apr 14, 2017	Jun 2, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
1353	Binding to voltage-gated sodium channel Short Name Binding to VGSC	0	Molecular	Apr 14, 2017	Nov 10, 2023	4 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 489: Inhibition of voltage-gated sodium channels leading to decreased cognition
1354	Treat, carbamazepine Short Name Treat, carbamazepine	0	Molecular	Apr 14, 2017	Apr 14, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
1355	Activated, membrane depolarization Short Name Activated, membrane depolarization	0	Cellular	Apr 14, 2017	Jun 2, 2017	3 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1356	Inactive, membrane depolarization Short Name Inactive, membrane depolarization	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1357	Increased, RDX dose Short Name Increased, RDX dose	0	Molecular	Apr 14, 2017	Jun 2, 2017	2 AOPs 215: Molecular events lead to epilepsy 231: presynaptic neuron 2 repression to epilepsy