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All KERs

Showing 251 to 275 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

177	167: Activation, LXR	264: Activation, SREBP-1c	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis
479	167: Activation, LXR	457: Activation, SREBF1	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
490	167: Activation, LXR	463: Up Regulation, FAS	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
491	167: Activation, LXR	462: Up Regulation, SCD-1	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
510	167: Activation, LXR	468: Inhibition, PPAR alpha	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
516	167: Activation, LXR	470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
3103	167: Activation, LXR	2199: Increased, Expression of LXR activated genes	Dec 7, 2023	Mar 29, 2024	1 AOP 518: Liver X Receptor (LXR) activation leads to liver steatosis
1606	483: Activation, LXR alpha	458: Increased, De Novo FA synthesis	Jul 18, 2017	Jul 18, 2017	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
2862	1998: Microglia activation	188: Neuroinflammation	Apr 3, 2023	Apr 3, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
1395	1300: Activation, mTORC1	1302: Activation, L-FABP	Apr 12, 2017	Apr 12, 2017	None
1396	1300: Activation, mTORC1	1303: Activation, HSD17B4	Apr 12, 2017	Apr 12, 2017	None
1399	1300: Activation, mTORC1	1301: Activation, SREBP-1	Apr 12, 2017	Apr 12, 2017	None
1392	1298: Activation, mTORC2	1299: Activation, AKT	Apr 12, 2017	Apr 12, 2017	None
1393	1298: Activation, mTORC2	1300: Activation, mTORC1	Apr 12, 2017	Apr 12, 2017	None
1858	1602: Activation, Muscarinic Acetylcholine Receptors	1350: Increased, glutamate	Feb 13, 2019	Feb 13, 2019	None
1889	1602: Activation, Muscarinic Acetylcholine Receptors	1623: Occurrence, Focal Seizure	Apr 22, 2019	Sep 3, 2023	1 AOP 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
1235	1174: Activation, NADPH Oxidase	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
1360	1174: Activation, NADPH Oxidase	1278: ROS formation	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
581	559: Activation, Nicotinic acetylcholine receptor	177: Mitochondrial dysfunction	Nov 29, 2016	Dec 3, 2016	5 AOPs 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
658	559: Activation, Nicotinic acetylcholine receptor	663: Desensitization, Nicotinic acetylcholine receptor	Nov 29, 2016	Jun 7, 2018	3 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
1146	559: Activation, Nicotinic acetylcholine receptor	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	4 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
1147	559: Activation, Nicotinic acetylcholine receptor	560: Abnormal, Foraging activity and behavior	Nov 29, 2016	Dec 3, 2016	None
533	479: Activation, NR1H4	480: Activation, SHP	Nov 29, 2016	Dec 3, 2016	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
534	479: Activation, NR1H4	227: Activation, PPARα	Nov 29, 2016	Dec 3, 2016	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
532	478: Activation, NRF2	479: Activation, NR1H4	Nov 29, 2016	Dec 3, 2016	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis

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