Key Event Relationships (KERs)

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Showing 2326 to 2350 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1861 613: Occurrence, Epileptic seizure 1350: Increased, glutamate Feb 13, 2019 Feb 13, 2019 None
1999 613: Occurrence, Epileptic seizure 388: Overactivation, NMDARs Nov 13, 2019 Nov 13, 2019 None
1890 1623: Occurrence, Focal Seizure 1350: Increased, glutamate Apr 22, 2019 Sep 3, 2023
1998 1623: Occurrence, Focal Seizure 388: Overactivation, NMDARs Nov 13, 2019 Nov 13, 2019 None
989 921: Goblet cell hyperplasia 943: Hypersecretion, Mucus Nov 29, 2016 Nov 29, 2016 None
1312 921: Goblet cell hyperplasia 962: Increase, Mucin production Nov 29, 2016 Aug 11, 2021 None
2472 921: Goblet cell hyperplasia 1251: Chronic, Mucus hypersecretion Aug 26, 2021 Aug 30, 2021 None
2648 814: Occurrence, Kidney toxicity 759: Increased, Kidney Failure Apr 8, 2022 Apr 8, 2022
990 920: Goblet cell metaplasia 943: Hypersecretion, Mucus Nov 29, 2016 Nov 29, 2016 None
1313 920: Goblet cell metaplasia 962: Increase, Mucin production Nov 29, 2016 Aug 11, 2021 None
2471 920: Goblet cell metaplasia 1251: Chronic, Mucus hypersecretion Aug 26, 2021 Aug 27, 2021 None
1139 1105: Occurrence, renal ischemia 1097: Occurrence, renal proximal tubular necrosis Nov 29, 2016 Dec 3, 2016 None
1159 1105: Occurrence, renal ischemia 1088: Increased, Oxidative Stress Nov 29, 2016 Dec 3, 2016
1134 1097: Occurrence, renal proximal tubular necrosis 1098: Increased, blood potassium concentration Nov 29, 2016 Dec 3, 2016
1156 1097: Occurrence, renal proximal tubular necrosis 1096: Increased, blood uric acid concentration Nov 29, 2016 Dec 3, 2016
2647 1097: Occurrence, renal proximal tubular necrosis 814: Occurrence, Kidney toxicity Apr 8, 2022 Apr 8, 2022
1133 1102: Occurrence, tophi (urate) deposition 1097: Occurrence, renal proximal tubular necrosis Nov 29, 2016 Dec 3, 2016
943 919: Occurrence, Transdifferentiation of ciliated epithelial cells 920: Goblet cell metaplasia Nov 29, 2016 Aug 11, 2021 None
2364 1872: Olfactory epithelium degeneration 1873: anosmia Apr 26, 2021 Apr 26, 2021
2363 1871: olfacotry neurons, decrease 1872: Olfactory epithelium degeneration Apr 26, 2021 Apr 26, 2021
2366 1871: olfacotry neurons, decrease 1873: anosmia Apr 26, 2021 Apr 26, 2021
3260 2246: Oligodendrocyte death, increased 2247: Demyelination, increased Sep 6, 2024 Sep 26, 2024
1272 1218: Opening of calcium channel, Calcium influx 1217: Sensory Airway Irritation Nov 29, 2016 Dec 3, 2016 None
1274 1218: Opening of calcium channel, Calcium influx 1220: Excitation, Trigeminal nerve excitation Nov 29, 2016 Dec 3, 2016
1280 1218: Opening of calcium channel, Calcium influx 1222: SP (Substance P) release, Local increase of SP Nov 29, 2016 Nov 29, 2016 None