Key Event Relationships (KERs)

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Showing 2476 to 2500 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1848 1593: Radical generation 1597: DNA photo-adducts Feb 4, 2019 Feb 4, 2019 None
1849 1593: Radical generation 1598: Protein photo-adducts Feb 4, 2019 Feb 4, 2019 None
1447 1329: Reduce expression, BDNF 1330: Decreased, neuroplasticity Apr 14, 2017 Apr 14, 2017
2695 2024: Reduced complex sphingolipids 2025: Affected folate transporter Jul 19, 2022 Jul 20, 2022
3127 2210: Reduced cortical thickness 2211: Microcephalus Feb 2, 2024 Feb 2, 2024 None
3143 2210: Reduced cortical thickness 1978: Microcephaly Mar 13, 2024 Mar 13, 2024
974 945: reduced dimerization, ARNT/HIF1-alpha 948: reduced production, VEGF Nov 29, 2016 Mar 23, 2018
1171 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction 1136: Impaired recruitment , Population trajectory Nov 29, 2016 Dec 3, 2016
348 381: BDNF, Reduced 382: Aberrant, Dendritic morphology Nov 29, 2016 Nov 29, 2016
353 381: BDNF, Reduced 55: Cell injury/death Nov 29, 2016 Nov 29, 2016
354 381: BDNF, Reduced 383: Reduced, Presynaptic release of glutamate Nov 29, 2016 Nov 29, 2016
445 381: BDNF, Reduced 427: Down Regulation, K-Cl co-transporter 2 (KCC2) Nov 29, 2016 Dec 3, 2016 None
448 381: BDNF, Reduced 385: Synaptogenesis, Decreased Nov 29, 2016 Apr 4, 2019
870 381: BDNF, Reduced 851: GABAergic interneurons, Decreased Nov 29, 2016 Jan 19, 2018
1507 381: BDNF, Reduced 341: Impairment, Learning and memory May 10, 2017 May 29, 2018
3190 2223: Reduced number of oligodendrocytes 2107: Hypomyelination Apr 12, 2024 Apr 12, 2024
975 948: reduced production, VEGF 110: Impairment, Endothelial network Nov 29, 2016 Mar 23, 2018
2407 948: reduced production, VEGF 1891: abnormal, placental labyrinth vasculature morphology May 31, 2021 May 31, 2021
2480 1883: Ovarian follicle pool, reduced 972: Decreased fertility, Reduced number of oocytes ovulated Sep 12, 2021 Sep 12, 2021 None
2487 1883: Ovarian follicle pool, reduced 406: impaired, Fertility Oct 10, 2021 Oct 10, 2021 None
2525 1883: Ovarian follicle pool, reduced 405: irregularities, ovarian cycle Oct 29, 2021 Nov 12, 2021
1975 1677: Reduced tidal volume 1678: Impaired oxygenation of the blood Jul 3, 2019 Jul 3, 2019 None
2257 1677: Reduced tidal volume 1833: Impaired lung function Jan 8, 2021 Jan 8, 2021 None
2367 1677: Reduced tidal volume 1250: Decreased lung function Apr 27, 2021 Apr 27, 2021
674 674: Reduced, Ability to attract spawning mates 675: Reduced, Reproductive Success Nov 29, 2016 Dec 3, 2016