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All KERs

Showing 26 to 50 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

584	560: Abnormal, Foraging activity and behavior	561: Reduced, Food storage	Nov 29, 2016	Dec 3, 2016	None
1144	560: Abnormal, Foraging activity and behavior	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	5 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 180: Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure 182: Weather event contributes abnormal foraging leading to colony loss/failure 183: Nosema infection increases energetic demands leading to colony loss/failure
1148	560: Abnormal, Foraging activity and behavior	564: Abnormal, Roll change within caste	Nov 29, 2016	Dec 3, 2016	None
1150	560: Abnormal, Foraging activity and behavior	1108: Abnormal, Role change within caste	Nov 29, 2016	Dec 3, 2016	2 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
2531	1952: Abnormal, Glucose homeostasis	1953: GDM	Nov 18, 2021	Nov 18, 2021	1 AOP 431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
196	183: Abnormal, Morphogenesis	342: Increased, Lethality	Nov 29, 2016	Dec 3, 2016	None
197	183: Abnormal, Morphogenesis	366: Increased, Structural malformations	Nov 29, 2016	Dec 3, 2016	None
1025	183: Abnormal, Morphogenesis	1001: Increased, Developmental Defects	Nov 29, 2016	Dec 3, 2016	None
2408	1891: abnormal, placental labyrinth vasculature morphology	1892: increase, placental insufficiency	May 31, 2021	May 31, 2021	1 AOP 151: AhR activation leading to preeclampsia
1151	1108: Abnormal, Role change within caste	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	3 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 184: Nosema infection causes abnormal role change that leads to colony loss/failure
565	564: Abnormal, Roll change within caste	565: Reduced, Brood care	Nov 29, 2016	Dec 3, 2016	3 AOPs 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
579	564: Abnormal, Roll change within caste	561: Reduced, Food storage	Nov 29, 2016	Dec 3, 2016	1 AOP 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
580	564: Abnormal, Roll change within caste	572: Decrease, Number of worker bees	Nov 29, 2016	Dec 3, 2016	None
1149	564: Abnormal, Roll change within caste	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	None
1843	1591: Absorption of photon energy	1592: ROS generation	Feb 4, 2019	Feb 4, 2019	None
1844	1591: Absorption of photon energy	1593: Radical generation	Feb 4, 2019	Feb 4, 2019	None
663	571: Accelerated, Aging	572: Decrease, Number of worker bees	Nov 29, 2016	Dec 3, 2016	1 AOP 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
1865	1605: Accumulation, misfolded proteins	1512: Unfolded Protein Response	Mar 6, 2019	Mar 6, 2019	1 AOP 285: Inhibition of N-linked glycosylation leads to liver injury
3045	1605: Accumulation, misfolded proteins	2017: Endoplasmic reticulum stress	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3046	1605: Accumulation, misfolded proteins	2188: Caspase activation	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
82	68: Accumulation, Collagen	344: N/A, Liver fibrosis	Nov 29, 2016	Dec 5, 2018	2 AOPs 38: Protein Alkylation leading to Liver Fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis
1629	68: Accumulation, Collagen	1458: Pulmonary fibrosis	Jul 26, 2017	May 18, 2023	2 AOPs 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
2139	68: Accumulation, Collagen	1276: Lung fibrosis	May 15, 2020	May 15, 2020	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis
2503	1942: Accumulation, Toxic Tau oligomers	1582: Impaired axonial transport	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
2507	1942: Accumulation, Toxic Tau oligomers	188: Neuroinflammation	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants

Key Event Relationships (KERs)

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