Key Event Relationships (KERs)

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Showing 1551 to 1575 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
280 252: Increase, Renal pathology due to VTG deposition 339: Altered, Larval development Nov 29, 2016 Dec 3, 2016
889 869: Increase, Respiratory or Squamous Metaplasia 870: Increase, Cell Proliferation Nov 29, 2016 Dec 1, 2016
1930 1652: Increase, SAM depletion 1620: Increase, DNA hypomethylation May 30, 2019 May 30, 2019 None
1460 1348: Increase, seizure 1363: Increased, epilepsy Apr 14, 2017 Apr 14, 2017
2742 2049: Increase, sex ratio (F/M) 2050: Increase, developmental abnormalities Aug 28, 2022 Aug 28, 2022
2684 2021: Increase, slincR expression 2020: Decrease, sox9 expression Jun 30, 2022 Sep 8, 2022
2690 2021: Increase, slincR expression 1559: Smaller and morphologically distorted facial cartilage structures Jun 30, 2022 Sep 8, 2022
2727 2021: Increase, slincR expression 317: Altered, Cardiovascular development/function Aug 2, 2022 Sep 8, 2022
1745 1525: Increase, SUR binding 1527: Increase, Cell membrane depolarization May 24, 2018 May 24, 2018
1489 1381: Increase, surfactant 1380: Activate, mucosal defense Apr 17, 2017 Apr 17, 2017
2064 1748: Increase, the risk of acute respiratory failure 1751: Decreased mortality Mar 17, 2020 Mar 17, 2020 None
2135 1748: Increase, the risk of acute respiratory failure 351: Increased Mortality May 13, 2020 May 13, 2020
741 753: Increase, Thyroid-stimulating hormone (TSH) 739: Increase, Hypertrophy and proliferation (follicular cell) Nov 29, 2016 Dec 3, 2016 None
888 868: Increase, Tissue Degeneration, Necrosis & Atrophy 869: Increase, Respiratory or Squamous Metaplasia Nov 29, 2016 Dec 1, 2016
2178 1809: Increase, Tissue/organ damage 1521: Decrease, Growth Nov 2, 2020 Nov 2, 2020 None
2528 1950: Increase, TNF 1949: Decrease, GLUT4 Nov 18, 2021 Nov 18, 2021
1663 1471: Increase, Uncoupling of photophosphorylation 1472: Decrease, ATP production Oct 10, 2017 Oct 10, 2017
795 793: Increase, Urinary bladder calculi 794: Increase, Cytotoxicity (urothelial cells) Nov 29, 2016 Dec 3, 2016
3018 2161: Increase, Vascular disrupting effects 2160: Angiogenesis disfunction Aug 21, 2023 Aug 21, 2023 None
1444 1342: Increase, vascular smooth muscle contraction 1343: Increase, hypertension Apr 14, 2017 Apr 14, 2017
2738 2046: Increase, Vitellogenin mRNA 2047: Delay, Ovarian maturation Aug 28, 2022 Aug 28, 2022
336 307: Increase, Vitellogenin synthesis in liver 220: Increase, Plasma vitellogenin concentrations Nov 29, 2016 Dec 3, 2016
2068 1745: Increase,collagen synthesis 1746: Induction lung fibrosis Mar 17, 2020 Mar 17, 2020 None
2527 1888: increased atRA concentration 1889: premature meiosis, male germ cells Nov 10, 2021 Nov 11, 2021
2509 1948: Upregulation of ACE2 1738: SARS-CoV-2 cell entry Oct 28, 2021 Oct 28, 2021 None