Key Event Relationships (KERs)

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Showing 201 to 225 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1294 1181: Activation, Estrogen receptor 1191: Increased, Non-genomic signaling Nov 29, 2016 Dec 3, 2016
1307 1181: Activation, Estrogen receptor 1242: Increased, Second Messenger Production Nov 29, 2016 Dec 3, 2016
1103 1065: Activation, estrogen receptor alpha 1066: Promotion, SIX-1 postive basal-type progenitor cells Nov 29, 2016 Dec 3, 2016
2665 1065: Activation, estrogen receptor alpha 1985: Increased, Kisspeptin signalling Jun 6, 2022 Aug 15, 2022
2666 1065: Activation, estrogen receptor alpha 1986: Decreased, Gonadotropins Jun 6, 2022 Aug 15, 2022
2730 1065: Activation, estrogen receptor alpha 1991: Impaired, Reproduction Aug 15, 2022 Aug 15, 2022
2969 1065: Activation, estrogen receptor alpha 2152: Epigenetic modification process Jul 27, 2023 Jul 27, 2023
133 116: Activation, FAS 89: Synthesis, De Novo Fatty Acid (FA) Nov 29, 2016 Dec 3, 2016
1422 116: Activation, FAS 1306: Increased, lipogenesis Apr 13, 2017 Apr 13, 2017 None
1381 1293: Activation, FOXO 1294: Inhibition, Wnt pathway Feb 15, 2017 Feb 15, 2017
1407 1304: Activation, FXR 480: Activation, SHP Apr 12, 2017 Apr 12, 2017 None
1408 1304: Activation, FXR 227: Activation, PPARĪ± Apr 12, 2017 Apr 12, 2017 None
385 122: Activation, Glucocorticoid Receptor 145: Induction, IKB inhibitory protein Nov 29, 2016 Dec 3, 2016
1451 122: Activation, Glucocorticoid Receptor 1335: Reduced, BDNF Apr 14, 2017 Apr 14, 2017
2039 122: Activation, Glucocorticoid Receptor 860: Decreased, Mitochondrial Fatty Acid Beta Oxidation Feb 22, 2020 Feb 22, 2020 None
2041 122: Activation, Glucocorticoid Receptor 231: Decreased, PPAR-alpha activation Feb 22, 2020 Feb 22, 2020 None
2077 122: Activation, Glucocorticoid Receptor 1759: Increase, Cripto-1 expression Apr 20, 2020 Jul 10, 2020
2261 122: Activation, Glucocorticoid Receptor 54: Up Regulation, CD36 Jan 15, 2021 Jan 15, 2021 None
2266 122: Activation, Glucocorticoid Receptor 1834: Decrease, ACAD Jan 15, 2021 Jan 15, 2021
752 760: Activation, Glutamate-gated chloride channel 761: Increased, Chloride conductance Nov 29, 2016 Dec 3, 2016
1057 1018: Activation, Glutamate-gated chloride channels 761: Increased, Chloride conductance Nov 29, 2016 Dec 3, 2016
3084 1018: Activation, Glutamate-gated chloride channels 388: Overactivation, NMDARs Oct 17, 2023 Oct 17, 2023
3085 1018: Activation, Glutamate-gated chloride channels 2195: Increase, CNS Neural cell death Oct 17, 2023 Oct 17, 2023
1204 1157: Activation, Hepatic nuclear receptor(s) 1158: Increased, Hepatic thyroid hormone uptake/transport Nov 29, 2016 Dec 3, 2016
1205 1157: Activation, Hepatic nuclear receptor(s) 295: Induction, Upregulation of glucuronyltransferase activity Nov 29, 2016 Dec 3, 2016