Key Event Relationships (KERs)

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Showing 2451 to 2475 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
931 249: Production, Reactive oxygen species 357: Cholestasis, Pathology Nov 29, 2016 Dec 3, 2016 None
332 302: Production, VEGF-A 301: Binding, VEGF-A Nov 29, 2016 Dec 3, 2016 None
333 302: Production, VEGF-A 304: Decreased, VegfR2 Nov 29, 2016 Dec 3, 2016 None
69 57: Proliferation, Cell proliferation in the absence of cytotoxicity 142: Hyperplasia, Hyperplasia Nov 29, 2016 Dec 3, 2016
1105 1067: Proliferation/Clonal Expansion, aberrant basal cells 1068: squamous metaplasia, aberrant basal cells Nov 29, 2016 Dec 3, 2016
1082 1042: Proliferation/Clonal Expansion, smooth muscle 1043: Hypertrophy/hyperplasia, smooth muscle Nov 29, 2016 Dec 3, 2016
2540 1961: Prolongation of Action Potential 1962: Prolongation of QT interval Dec 13, 2021 Dec 13, 2021
2541 1962: Prolongation of QT interval 1963: Torsades de Pointes Dec 13, 2021 Dec 13, 2021
2853 1962: Prolongation of QT interval 1106: Occurrence, cardiac arrhythmia Jan 29, 2023 Jan 29, 2023 None
2429 1842: TLR9 activation 1897: MyD88 activation Jul 8, 2021 Jul 8, 2021
2433 1842: TLR9 activation 1895: inflammasome activity, increased Jul 8, 2021 Jul 8, 2021
604 599: prolonged, Depolarization of neuronal membrane 600: Overactivation, Neuronotransmitter release Nov 29, 2016 Dec 3, 2016
1098 1061: prolonged, elevation of serun CCK 1062: Increased, Cellular proliferation / hyperplasia of acinar cells Nov 29, 2016 Dec 3, 2016
1111 1075: prolonged, estrus 1076: Increased, circulating estrogen levels Nov 29, 2016 Dec 3, 2016
1112 1075: prolonged, estrus 1077: Increased, prolactin exposure Nov 29, 2016 Dec 3, 2016
2829 1053: Promotion, ovarian adenomas 2092: Promotion, Ovarian Cancer Jan 13, 2023 Mar 11, 2023
2830 1054: Promotion, ovarian granular cell tumors 2092: Promotion, Ovarian Cancer Jan 13, 2023 Jan 13, 2023 None
1104 1066: Promotion, SIX-1 postive basal-type progenitor cells 1067: Proliferation/Clonal Expansion, aberrant basal cells Nov 29, 2016 Dec 3, 2016
240 211: Propagation, Oxidative stress 131: Down Regulation, Gulcose-6-phosphate dehydrogenase Nov 29, 2016 Dec 3, 2016
241 211: Propagation, Oxidative stress 250: Damaging, Red blood cells; hemolysis Nov 29, 2016 Dec 3, 2016
2912 2136: prostatic intraepithelial neoplasia 2135: Prostate cancer May 11, 2023 May 11, 2023
1837 1585: Proteasomal dysfunction 1586: Airway epithelial injury Jan 30, 2019 Jan 30, 2019
3044 1585: Proteasomal dysfunction 1605: Accumulation, misfolded proteins Sep 14, 2023 Sep 14, 2023
1729 1509: Protein Adduct Formation 1512: Unfolded Protein Response Apr 4, 2018 Apr 5, 2018
2679 2010: Pulmonary inflammation 2008: Chronic obstructive pulmonary disease Jun 17, 2022 Jun 17, 2022