Stressor: 451

Title

Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE).  It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help

Ionizing Radiation

Stressor Overview

A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help

AOPs Including This Stressor

This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help
AOP Name Evidence
Increased DNA damage leading to increased risk of breast cancer High
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer High
Oxidative DNA damage leading to chromosomal aberrations and mutations High
Deposition of energy leading to lung cancer High
Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer Moderate
Deposition of energy leading to population decline via DNA strand breaks and follicular atresia High
Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis High
Deposition of ionizing energy leading to population decline via inhibition of photosynthesis High
Deposition of ionising energy leading to population decline via mitochondrial dysfunction High
Deposition of ionising energy leading to population decline via programmed cell death High
Deposition of energy leading to population decline via DNA oxidation and follicular atresia High
Deposition of ionizing energy leads to population decline via impaired meiosis High
Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation High
Deposition of energy leads to vascular remodeling
Deposition of Energy Leading to Learning and Memory Impairment
Deposition of energy leading to occurrence of bone loss
Deposition of energy leading to occurrence of cataracts

Chemical Table

A list of chemicals associated with a prototypical stressor. More help

References

List of the literature that was cited for this prototypical stressor. More help