Prototypical Stressors

Showing 401 to 425 of 777 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

282	Ketoconazole	Ketoconazole, CAS-RN: 65277-42-1, DTXSID7029879	3 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
181	Ketoprofen	Ketoprofen, CAS-RN: 22071-15-4, DTXSID6020771	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
186	Ketorolac Tromethamine	Ketorolac tromethamine, CAS-RN: 74103-07-4, DTXSID0045597	None
217	kinoprene	Kinoprene, CAS-RN: 42588-37-4, DTXSID3032624	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
109	Lambda-Cyhalothrin	λ-Cyhalothrin, CAS-RN: 91465-08-6, DTXSID7032559	None
59	Lead	Lead, CAS-RN: 7439-92-1, DTXSID2024161	3 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
30	Lead(II)		None
31	Lead(II) acetate trihydrate	Lead(II) acetate trihydrate, CAS-RN: 6080-56-4, DTXSID3031521	None
760	Lei Gong Teng (Common Threewingnut Root)		486: Binding to the extracellular protein laminin leading to decreased cognitive function
32	Letrozole	Letrozole, CAS-RN: 112809-51-5, DTXSID4023202 Fadrozole, CAS-RN: 102676-47-1, DTXSID5034141	2 AOPs 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
161	Levothyroxine	Levothyroxine, CAS-RN: 51-48-9, DTXSID8023214	None
694	Liarozole	Liarozole, CAS-RN: 115575-11-6, DTXSID9048277	None
483	LiCl		None
99	Lidocaine	Lidocaine, CAS-RN: 137-58-6, DTXSID1045166	None
415	Light (290-700 nm)		282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
112	Lindane	Lindane, CAS-RN: 58-89-9, DTXSID2020686	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
564	Linuron	Linuron, CAS-RN: 330-55-2, DTXSID2024163	None
376	Lipopolysaccharride	Lipopolysaccharride, CAS-RN: NOCAS, DTXSID4036695	237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
551	Losartan	Losartan, CAS-RN: 114798-26-4, DTXSID7023227	319: Binding to ACE2 leading to lung fibrosis
502	Low LET Radiation		None
334	low molecular weight proteins		257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
374	LPS		None
575	Lysodren, Mitotan, Mitotane	Lysodren, Mitotan, Mitotane, CAS-RN: 164203-73-0, DTXSID30425146	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
245	Makisterone A		4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
546	Malathion	Malathion, CAS-RN: 121-75-5, DTXSID4020791	None