AOPs

OECD View API
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Showing 451 to 475 of 476 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
511 The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects Evgeniia Kazymova BY-SA 257: Increase, Reactive Oxygen Species production 2161: Increase, Vascular disrupting effects
512 Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level Cataia Ives BY-SA None None
513 Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway Brendan Ferreri-Hanberry BY-SA 1115: Increased, Reactive oxygen species 885: Increase, Cancer
514 PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV Arthur Author BY-SA None None
515 An overview of adverse outcome pathway linked between PM2.5 exposure and congenital heart defects Agnes Aggy BY-SA None None
516 Na+ /K+ -ATPase inhibition leading to hypertension Allie Always BY-SA 1562: Decreased Na/K ATPase activity 952: Hypertension
517 Pregnane X Receptor (PXR) activation leads to liver steatosis Evgeniia Kazymova BY-SA 239: Activation, Pregnane-X receptor, NR1l2 459: Increased, Liver Steatosis
518 Liver X Receptor (LXR) activation leads to liver steatosis Cataia Ives BY-SA 167: Activation, LXR 459: Increased, Liver Steatosis
519 Cardiac ion channels blockade leading to arrhythmia associated sudden cardiac death Brendan Ferreri-Hanberry Open for adoption None None
520 Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory Arthur Author Open for adoption 2201: Agonism, Retinoic acid receptor 341: Impairment, Learning and memory
521 Essential element imbalance leads to reproductive failure via oxidative stress Agnes Aggy BY-SA 2205: Increased, essential element imbalance 2147: Decreased, Viable Offspring
522 Estrogen antagonism leading to increased risk of autism-like behavior Allie Always Open for adoption 112: Antagonism, Estrogen receptor 2209: autism-like behavior
523 Retinoic acid receptor agonism during neurodevelopment leading to microcephaly Evgeniia Kazymova Open for adoption 2201: Agonism, Retinoic acid receptor 1978: Increase risk, microcephaly
524 Gluten intake leading to celiac disease example test - under development Cataia Ives BY-SA None None
525 Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory Brendan Ferreri-Hanberry Open for adoption 341: Impairment, Learning and memory
526 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis Arthur Author BY-SA None 1758: Impaired, Spermatogenesis
527 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased Agnes Aggy BY-SA None 2082: Hypospadias, increased
528 Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis Allie Always BY-SA None 1616: Malformation, cryptorchidism - maldescended testis
529 Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis Evgeniia Kazymova BY-SA 2226: Stressor binding PPAR isoforms 459: Increased, Liver Steatosis
530 Endocytotic lysosomal uptake leads to intestinal barrier disruption Cataia Ives BY-SA 1539: Endocytotic lysosomal uptake 1931: Intestinal barrier, disruption
531 VEGFR inhibition leading to Keratinocyte differentiation-associate Hand-foot skin reaction Brendan Ferreri-Hanberry BY-SA None None
532 CYP450 upregulation leads to Chronic kidney disease Arthur Author BY-SA 2228: CYP450 Upregulation 1603: Chronic kidney disease
533 C6R-Derived Protein K7 following Monkeypox infection leads to heart failure Arthur Author BY-SA 2234: Binding of C6R-Derived Protein K7 2236: Cardiac Heart Failure
534 Activation of Protein kinase C leads to Kidney Failure Arthur Author BY-SA 2240: Activation, Protein Kinase C (PKC) 759: Increased, Kidney Failure
535 Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration Travis Karschnik BY-SA 2243: Neuropathy target esterase, inhibited 2248: Delayed neuropathy, increased