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All Key Events

Showing 526 to 550 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

934	KE3 : Decrease, Tetrahydrobiopterin Short Name Decrease, Tetrahydrobiopterin	1	Cellular	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
935	KE2 : Decrease, GTPCH-1 Short Name Decrease, GTPCH-1	1	Cellular	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
937	KE7 : Impaired, Vasodilation Short Name Impaired, Vasodilation	1	Organ	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
941	Activation, EGFR Short Name Activation, EGFR	2	Molecular	Nov 29, 2016	Mar 8, 2023	148: EGFR Activation Leading to Decreased Lung Function
943	Hypersecretion, Mucus Short Name Hypersecretion, Mucus	0	Organ	Nov 29, 2016	Nov 29, 2016	None
944	dimerization, AHR/ARNT Short Name dimerization, AHR/ARNT	2	Molecular	Nov 29, 2016	Sep 16, 2017	6 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 151: AhR activation leading to preeclampsia 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
945	reduced dimerization, ARNT/HIF1-alpha Short Name reduced dimerization, ARNT/HIF1-alpha	2	Molecular	Nov 29, 2016	Mar 23, 2018	2 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 151: AhR activation leading to preeclampsia
947	Increase, Early Life Stage Mortality Short Name Increase, Early Life Stage Mortality	2	Individual	Nov 29, 2016	Mar 22, 2018	4 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
948	reduced production, VEGF Short Name reduced production, VEGF	2	Cellular	Nov 29, 2016	Mar 28, 2018	2 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 151: AhR activation leading to preeclampsia
951	KE8 : Increase, Vascular Resistance Short Name Increase, Vascular Resistance	1	Organ	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
952	Hypertension Short Name Hypertension	1	Individual	Nov 29, 2016	Sep 27, 2017	2 AOPs 149: Peptide Oxidation Leading to Hypertension 516: Na+ /K+ -ATPase inhibition leading to hypertension
957	Binding, Transthyretin in serum Short Name Binding, Transthyretin in serum	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
958	Displacement, Serum thyroxine (T4) from transthyretin Short Name	1	Molecular	Nov 29, 2016	Dec 17, 2016	152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
959	Increased, Free serum thyroxine (T4) Short Name Increased, Free serum thyroxine (T4)	1	Tissue	Nov 29, 2016	Sep 16, 2017	3 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
960	Increased, Uptake of thyroxine into tissue Short Name	1	Cellular	Nov 29, 2016	Dec 17, 2016	152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
961	Increased, Clearance of thyroxine from serum Short Name	1	Tissue	Nov 29, 2016	Jan 26, 2021	7 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
962	Increase, Mucin production Short Name Increase, Mucin production	2	Cellular	Nov 29, 2016	Mar 9, 2023	148: EGFR Activation Leading to Decreased Lung Function
964	Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
965	reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
966	Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation Short Name	1	Tissue	Nov 29, 2016	Dec 3, 2016	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
967	Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus Short Name	1	Organ	Nov 29, 2016	Dec 3, 2016	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
968	Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
969	Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
970	Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
971	Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation Short Name Reduced Ovulation of oocytes	1	Individual	Nov 29, 2016	May 19, 2020	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats