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All Key Events

Showing 1426 to 1450 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1889	Premature initiation of meiosis in fetal male germ cells Short Name premature meiosis, male germ cells	0	Cellular	May 29, 2021	Nov 11, 2021	400: Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males
1890	Decrease (loss of) fetal male germ cells Short Name Germ cell loss, male	0	Cellular	May 29, 2021	Nov 11, 2021	400: Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males
1891	abnormal, placental labyrinth vasculature morphology Short Name	0	Tissue	May 31, 2021	May 31, 2021	151: AhR activation leading to preeclampsia
1892	increase, placental insufficiency Short Name increase, placental insufficiency	0	Organ	May 31, 2021	May 31, 2021	151: AhR activation leading to preeclampsia
1893	increase, Preeclampsia Short Name increase, Preeclampsia	0	Individual	May 31, 2021	May 31, 2021	151: AhR activation leading to preeclampsia
1894	chronic low grade systemic inflammation Short Name low grade inflammation	0	Individual	Jun 24, 2021	Jun 24, 2021	None
1895	NLRP3 inflammasome activity, increased Short Name inflammasome activity, increased	1	Molecular	Jun 25, 2021	Jun 25, 2021	3 AOPs 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1896	Genomic instability Short Name Genomic instability	1	Cellular	Jul 6, 2021	Jul 6, 2021	2 AOPs 409: Frustrated phagocytosis leads to malignant mesothelioma 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
1897	increased MyD88 activation Short Name MyD88 activation	0	Molecular	Jul 8, 2021	Jul 8, 2021	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1898	increased release of danger/damage associated molecular patterns Short Name increased release of DAMPS	0	Tissue	Jul 8, 2021	Jul 8, 2021	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1899	formation of neutrophil extracellular traps (NETs) Short Name NETosis	0	Cellular	Jul 8, 2021	Jul 8, 2021	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1900	increased platelet surface TLR9 expression Short Name increased platelet tlr9 expression	0	Cellular	Jul 8, 2021	Jul 8, 2021	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1901	Interferon-I antiviral response, antagonized by SARS-CoV-2 Short Name IFN-I response, antagonized	3	Cellular	Jul 9, 2021	Dec 15, 2023	5 AOPs 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
1902	Repression of Gbx2 expression Short Name Repression of Gbx2 expression	0	Molecular	Jul 14, 2021	Oct 7, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1903	foxi1 expression, increased Short Name foxi1 expression, increased	0	Molecular	Jul 14, 2021	Oct 28, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1904	six1b expression, increased Short Name six1b expression, increased	0	Molecular	Jul 14, 2021	Aug 12, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1905	eya1 expression, inhibited Short Name eya1 expression, inhibited	0	Molecular	Jul 14, 2021	Oct 7, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1906	Cystic Fibrosis Transmembrane Regulator Function, Decreased Short Name CFTR Function, Decreased	1	Molecular	Jul 19, 2021	Aug 3, 2021	424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
1907	Airway Surface Liquid Height, Decreased Short Name ASL Height, Decreased	1	Tissue	Jul 19, 2021	Sep 9, 2021	424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
1908	Cilia Beat Frequency, Decreased Short Name CBF, Decreased	1	Cellular	Jul 19, 2021	Sep 10, 2021	3 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
1909	Mucociliary Clearance, Decreased Short Name MCC, Decreased	1	Individual	Jul 19, 2021	Sep 10, 2021	3 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
1910	Mucus Viscosity, Increased Short Name Mucus Viscosity, Increased	1	Organ	Jul 19, 2021	Sep 9, 2021	None
1911	FOXJ1 Protein, Decreased Short Name FOXJ1 Protein, Decreased	1	Cellular	Jul 23, 2021	Sep 10, 2021	425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
1912	Motile Cilia Number/Length, Decreased Short Name Motile Cilia Number/Length, Decreased	1	Cellular	Jul 23, 2021	Sep 10, 2021	425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
1913	Endothelial cell dysfunction Short Name Endothelial cell dysfunction	0	Cellular	Aug 4, 2021	Aug 4, 2021	2 AOPs 412: Endothelial cell dysfunction leading to thromboinflammation 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.