AOP-Wiki

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All Key Events

Showing 476 to 500 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

845	Inhibition, UROD Short Name Inhibition, UROD	1	Molecular	Nov 29, 2016	May 30, 2018	131: Aryl hydrocarbon receptor activation leading to uroporphyria
846	Accumulation, Highly carboxylated porphyrins Short Name	1	Organ	Nov 29, 2016	May 7, 2018	131: Aryl hydrocarbon receptor activation leading to uroporphyria
848	Decreased, Binding of NE to NE receptors on GnRH neurons Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
849	Inhibition, Antgonism of NE receptor Short Name Inhibition, Antgonism of NE receptor	1	Molecular	Nov 29, 2016	Dec 3, 2016	126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
850	Induction, CYP1A2/CYP1A5 Short Name Induction, CYP1A2/CYP1A5	2	Molecular	Nov 29, 2016	May 30, 2018	2 AOPs 131: Aryl hydrocarbon receptor activation leading to uroporphyria 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
851	Decrease of GABAergic interneurons Short Name GABAergic interneurons, Decreased	1	Cellular	Nov 29, 2016	Apr 4, 2019	54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
853	Changes/Inhibition, Cellular Homeostasis and Apoptosis Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	41: Sustained AhR Activation leading to Rodent Liver Tumours
854	Alterations, Cellular proliferation / hyperplasia Short Name	3	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 41: Sustained AhR Activation leading to Rodent Liver Tumours 495: Androgen receptor activation leading to prostate cancer
856	Formation, Hepatocellular and Bile duct tumors Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	41: Sustained AhR Activation leading to Rodent Liver Tumours
857	Binding as antagonist, Antagonist binding to PPARalpha ligand binding domain Short Name	0	Molecular	Nov 29, 2016	Nov 29, 2016	None
858	Decreased, PPARalpha transactivation of gene expression Short Name	1	Molecular	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
859	Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	None
860	Decreased, Mitochondrial Fatty Acid Beta Oxidation Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	318: Glucocorticoid Receptor activation leading to hepatic steatosis
861	Decreased, Ketogenesis (production of ketone bodies) Short Name	1	Cellular	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
862	Not Increased, Circulating Ketone Bodies Short Name	2	Tissue	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
863	Increased, Catabolism of Muscle Protein Short Name Increased, Catabolism of Muscle Protein	1	Organ	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
864	Decreased, Body Weight Short Name Decreased, Body Weight	1	Individual	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
867	Decrease, Intracellular pH Short Name Decrease, Intracellular pH	1	Cellular	Nov 29, 2016	Sep 16, 2017	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
868	Increase, Tissue Degeneration, Necrosis & Atrophy Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
869	Increase, Respiratory or Squamous Metaplasia Short Name	1	Tissue	Nov 29, 2016	Sep 29, 2017	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
870	Increase, Cell Proliferation Short Name Increase, Cell Proliferation	2	Cellular	Nov 29, 2016	Mar 8, 2024	8 AOPs 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors 303: Frustrated phagocytosis-induced lung cancer 272: Deposition of energy leading to lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 451: Interaction with lung resident cell membrane components leads to lung cancer 478: Deposition of energy leading to occurrence of cataracts
872	Increase, Site of Contact Nasal Tumors Short Name Increase, Site of Contact Nasal Tumors	1	Organ	Nov 29, 2016	Sep 16, 2017	2 AOPs 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors 368: Cytochrome oxidase inhibition leading to olfactory nasal lesions
875	Binding of agonist, Ionotropic glutamate receptors Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
876	Increase, Mutations in Critical Genes Short Name Increase, Mutations in Critical Genes	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
877	Inhibition, organic anion transporter 1 (OAT1) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality