AOP-Wiki

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All Key Events

Showing 676 to 700 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1102	Occurrence, tophi (urate) deposition Short Name Occurrence, tophi (urate) deposition	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1103	Inhibition, Cyclooxygenase 1 activity Short Name Inhibition, Cyclooxygenase 1 activity	1	Molecular	Nov 29, 2016	Dec 3, 2016	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1104	Decreased, Prostaglandin F2alpha concentration, plasma Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1105	Occurrence, renal ischemia Short Name Occurrence, renal ischemia	1	Tissue	Nov 29, 2016	Dec 3, 2016	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1106	Occurrence, cardiac arrhythmia Short Name Occurrence, cardiac arrhythmia	1	Organ	Nov 29, 2016	Sep 16, 2017	3 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
1107	Weakened, Colony Short Name Weakened, Colony	1	Population	Nov 29, 2016	Jun 7, 2018	13 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure 178: Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure 179: Varroa mite infestation increases virus levels leading to colony loss/failure 180: Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure 181: Weather event contributes to colony loss/failure 182: Weather event contributes abnormal foraging leading to colony loss/failure 183: Nosema infection increases energetic demands leading to colony loss/failure 184: Nosema infection causes abnormal role change that leads to colony loss/failure 185: Queen egg-laying decrease leads to colony loss/failure
1108	Abnormal, Role change within caste Short Name Abnormal, Role change within caste	1	Population	Nov 29, 2016	Jun 7, 2018	3 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 184: Nosema infection causes abnormal role change that leads to colony loss/failure
1109	Increased, Deformed Wing Virus levels Short Name Increased, Deformed Wing Virus levels	1	Individual	Nov 29, 2016	Dec 3, 2016	179: Varroa mite infestation increases virus levels leading to colony loss/failure
1110	Increased, Energetic demands and therefore metabolic stress Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	183: Nosema infection increases energetic demands leading to colony loss/failure
1111	weaj, Short Name weaj,	0		Nov 29, 2016	Nov 29, 2016	None
1113	Unknown, Short Name Unknown,	0		Nov 29, 2016	Nov 29, 2016	None
1114	Unknown, MIE Short Name Unknown, MIE	0	Molecular	Nov 29, 2016	Dec 3, 2016	2 AOPs 186: unknown MIE leading to renal failure and mortality 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition
1115	Increased, Reactive oxygen species Short Name Increased, Reactive oxygen species	1	Cellular	Nov 29, 2016	Jan 29, 2025	22 AOPs 186: unknown MIE leading to renal failure and mortality 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) 303: Frustrated phagocytosis-induced lung cancer 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease 396: Deposition of ionizing energy leads to population decline via impaired meiosis 409: Frustrated phagocytosis leads to malignant mesothelioma 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 319: Binding to ACE2 leading to lung fibrosis 451: Interaction with lung resident cell membrane components leads to lung cancer 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway 521: Essential element imbalance leads to reproductive failure via oxidative stress
1116	Decreased, Triiodothyronine (T3) in tissues Short Name	2	Tissue	Nov 29, 2016	Sep 1, 2020	2 AOPs 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
1117	Irreversible inhibition of VKOR by binding at tyrosine 139, Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1118	Irreversible inhibition of VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1119	Failure in gamma-glutamyl carboxylation of glutamine residues on clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin) Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1120	Under carboxylated clotting factors will not assemble on cell surfaces , Failure to form clot Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1121	Hemorrhage , organ dysfunction, hypovolemic shock Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1122	Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis Short Name	1	Tissue	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1123	Hemorrhage, organ dysfunction, hypovolemic shock, Impaired oxygen delivery to tissue Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1124	Hemorrhage , Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1125	Impaired oxygen and nutrient delivery to tissue, impaired removal of carbon dioxide and other waste products, Hemorrhage, organ dysfunction and hypovolemic shock Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1126	Unresolved blood loss, Failure in vascular repair mechanisms Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1127	Anemia, Impaired oxygen and nutrient delivery to tissue, impaired carbon dioxide and waste product removal Short Name	0		Nov 29, 2016	Nov 29, 2016	None