AOP-Wiki

API

All Key Events

Showing 1351 to 1375 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1812	Increase, Cytochrome c release Short Name Increase, Cyt c release	0	Cellular	Nov 2, 2020	Nov 2, 2020	464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1813	Increase, Mitochondrial complex I dysfunction Short Name Increase, Complex I dysfunction	0	Molecular	Nov 2, 2020	Nov 2, 2020	None
1814	benzoquinone imine and acylglucuronide metabolites Short Name Reactive Metabolite	0	Molecular	Nov 2, 2020	Nov 2, 2020	362: Immune mediated hepatitis
1815	Activation of ER stress Short Name ER stress	0	Cellular	Nov 2, 2020	Nov 2, 2020	2 AOPs 362: Immune mediated hepatitis 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
1816	Mitochondrial dysfunction EMPTY Short Name Mitochondrial dysfunction EMPTY	0	Cellular	Nov 2, 2020	Apr 17, 2024	429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
1817	Apoptotic cell death Short Name Apoptotic cell death	0	Cellular	Nov 2, 2020	Nov 2, 2020	2 AOPs 362: Immune mediated hepatitis 423: Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway
1818	Immune cell activation Short Name Immune cell activation	0	Cellular	Nov 2, 2020	Nov 2, 2020	362: Immune mediated hepatitis
1819	IFNγ signaling Short Name IFNγ signaling	0	Cellular	Nov 2, 2020	Nov 2, 2020	362: Immune mediated hepatitis
1820	Immune mediated hepatitis Short Name hepatitis	0	Organ	Nov 2, 2020	Nov 2, 2020	362: Immune mediated hepatitis
1821	Decrease, Cell proliferation Short Name Decrease, Cell proliferation	1	Cellular	Nov 12, 2020	Dec 7, 2020	8 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 460: Antagonism of Smoothened receptor leading to orofacial clefting 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting
1822	Maturation of TNF/iNOS-Producing Dendritic Cells Short Name	0	Cellular	Nov 23, 2020	Nov 23, 2020	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
1824	Decrease, Fatty acid β-oxidation Short Name Decrease, FAO	0	Cellular	Nov 25, 2020	Nov 25, 2020	None
1825	Increase, Cell death Short Name Increase, Cell death	1	Cellular	Dec 4, 2020	Mar 22, 2023	9 AOPs 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2) 287: Mitochondrial complex III antagonism leading to growth inhibition (2) 368: Cytochrome oxidase inhibition leading to olfactory nasal lesions 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) 482: Deposition of energy leading to occurrence of bone loss
1826	Increase, Oxygen consumption Short Name Increase, Oxygen consumption	0	Cellular	Dec 4, 2020	Dec 4, 2020	None
1827	Increase, Global DNA methylation Short Name Increase, Global methylation	0	Molecular	Dec 4, 2020	Dec 4, 2020	326: Thermal stress leading to population decline (3)
1828	Increased, Thyroxine (T4) in serum Short Name Increased, Thyroxine (T4) in serum	0	Organ	Dec 9, 2020	Dec 9, 2020	190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
1829	Altered, Thyroid hormone-dependent gene expression Short Name Altered, TH-dependent gene expression	2	Molecular	Dec 9, 2020	Dec 9, 2020	4 AOPs 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis 191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation 402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
1830	Displacement, Serum thyroxine (T4) from carrier protein Short Name	0	Molecular	Dec 9, 2020	Dec 9, 2020	2 AOPs 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
1831	Binding, Thyroid binding globulin in serum Short Name	0	Molecular	Dec 9, 2020	Dec 9, 2020	367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
1832	Coordinated gene expression changes by PPARα activation Short Name Coordinated gene expression changes	1	Molecular	Dec 19, 2020	Dec 19, 2020	None
1833	Impaired lung function Short Name Impaired lung function	0	Individual	Jan 8, 2021	Feb 16, 2021	None
1834	Decrease, Acyl-CoA dehydrogenases Short Name Decrease, ACAD	0	Molecular	Jan 15, 2021	Jan 15, 2021	318: Glucocorticoid Receptor activation leading to hepatic steatosis
1835	Cortisol and 11β-(OH) testosterone decreased Short Name	0	Cellular	Feb 9, 2021	Feb 9, 2021	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
1836	Decreased plasma Cortisol level Short Name Decreased plasma Cortisol level	0	Tissue	Feb 9, 2021	Feb 9, 2021	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
1837	decreased oocyte maturation Short Name decreased oocyte maturation	0	Organ	Feb 9, 2021	Feb 9, 2021	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory