AOP-Wiki

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All Key Events

Showing 1501 to 1525 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1964	Sudden cardiac death Short Name Sudden cardiac death	0	Individual	Dec 13, 2021	Dec 13, 2021	433: hERG channel blockade leading to sudden cardiac death
1965	Increase, Pollen abnormal Short Name Increase, Pollen abnormal	0	Organ	Jan 13, 2022	Jan 13, 2022	435: Deposition of ionising energy leads to population decline via pollen abnormal
1966	Decrease, Asexual reproduction Short Name Decrease, Asexual reproduction	0	Individual	Jan 17, 2022	Jan 17, 2022	None
1967	Pyroptosis Short Name Pyroptosis	0	Cellular	Jan 18, 2022	Jan 19, 2022	407: SARS-CoV-2 infection leading to pyroptosis
1969	Increase, Oxidative Stress Short Name Increase, Oxidative Stress	0	Molecular	Feb 4, 2022	Mar 3, 2022	7 AOPs 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 510: Demethylation of PPAR promotor leading to vascular disrupting effects 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
1970	transposition of the great arteries Short Name Transposition of the great arteries	0	Organ	Feb 8, 2022	Feb 15, 2022	436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1971	Increased, tumor growth Short Name tumor growth	1	Organ	Feb 15, 2022	Feb 29, 2024	439: Activation of the AhR leading to metastatic breast cancer
1972	Increased, Steroidogenic acute regulatory protein (StAR) Short Name	4	Cellular	Feb 25, 2022	Mar 1, 2022	440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1973	Increased, estrogens Short Name Increased, estrogens	1	Cellular	Feb 25, 2022	Mar 1, 2022	2 AOPs 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
1974	Activation of Tumor Protein 53 Short Name Activation of TP53	0	Cellular	Mar 9, 2022	Mar 17, 2022	441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
1977	Disruption of sodium channel gating kinetics Short Name Altered kinetics of sodium channel	0	Cellular	Mar 15, 2022	Sep 13, 2022	2 AOPs 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 489: Inhibition of voltage-gated sodium channels leading to decreased cognition
1978	Increase risk, microcephaly Short Name Microcephaly	0	Individual	Mar 17, 2022	Mar 18, 2022	2 AOPs 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
1979	Premature cell differentiation Short Name Premature differentiation	0	Organ	Mar 21, 2022	Mar 21, 2022	441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
1980	Increased microRNA expression Short Name Increase,miRNA levels	0	Cellular	Mar 22, 2022	Aug 27, 2023	443: DNA damage and mutations leading to Metastatic Breast Cancer
1981	Decreased SIRT1 expression Short Name Decrease,SIRT1(sirtuin 1) levels	0	Cellular	Mar 22, 2022	Mar 24, 2022	443: DNA damage and mutations leading to Metastatic Breast Cancer
1982	metastatic breast cancer Short Name Metastasis, Breast Cancer	0	Organ	Mar 22, 2022	May 14, 2024	2 AOPs 443: DNA damage and mutations leading to Metastatic Breast Cancer 439: Activation of the AhR leading to metastatic breast cancer
1983	Disruption, action potential Short Name	1	Cellular	Mar 31, 2022	Mar 31, 2022	442: Binding to voltage gate sodium channels during development leads to cognitive impairment
1984	Agonism, Estrogen Receptor alpha Short Name Agonism, Estrogen Receptor alpha	0	Molecular	Apr 5, 2022	Apr 5, 2022	None
1985	Increased, Kisspeptin signalling Short Name Increased, Kisspeptin signalling	0	Molecular	Apr 5, 2022	Apr 5, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1986	Decreased, Gonadotropins Short Name Decreased, Gonadotropins	0	Molecular	Apr 5, 2022	Apr 5, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1987	Decreased, Androgen and Progestin Short Name Decreased , Androgen and Progestin	0	Cellular	Apr 5, 2022	Jun 6, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1988	Decreased, Maturation Inducing Steroid Surge by Granulosa cells Short Name	0	Tissue	Apr 5, 2022	Apr 5, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1989	Impaired, Oocyte maturation and ovulation Short Name	0	Tissue	Apr 5, 2022	Apr 5, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1990	Increased, Oocyte Atresia Short Name Increased, Oocyte Atresia	0	Tissue	Apr 5, 2022	Apr 5, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1991	Impaired, Reproduction Short Name Impaired, Reproduction	0	Population	Apr 5, 2022	Apr 5, 2022	445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction