Key Event Relationships (KERs)

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Showing 2651 to 2675 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3220 2226: Binding PPAR isoforms 2227: Disrupted PPAR isoform nuclear signaling May 14, 2024 May 23, 2024
1968 1671: Substance - LS interaction 1672: Inhibition of LS function. Jul 3, 2019 Jul 3, 2019 None
1702 1495: Interaction with the lung cell membrane 1496: Increased proinflammatory mediators Jan 5, 2018 Aug 29, 2023
2662 1495: Interaction with the lung cell membrane 1115: Increased, Reactive oxygen species May 25, 2022 May 25, 2022
2663 1495: Interaction with the lung cell membrane 1669: Increased, DNA damage and mutation May 25, 2022 May 25, 2022
2958 1495: Interaction with the lung cell membrane 1438: Increased transcription of genes encoding acute phase proteins Jul 4, 2023 Dec 19, 2023
2959 1495: Interaction with the lung cell membrane 1439: Systemic acute phase response Jul 4, 2023 Dec 19, 2023
2960 1495: Interaction with the lung cell membrane 1443: Atherosclerosis Jul 4, 2023 Dec 18, 2023
2866 2118: SDH, inhibited 2120: Superoxide generation, increased Apr 3, 2023 May 4, 2023
2895 2118: SDH, inhibited 1969: Increase, Oxidative Stress Apr 24, 2023 Apr 24, 2023 None
2896 2120: Superoxide generation, increased 1969: Increase, Oxidative Stress Apr 24, 2023 Jun 1, 2023
1817 1565: Suppressed AP-1 1567: Suppressed DC activation Dec 25, 2018 Dec 25, 2018 None
1819 1567: Suppressed DC activation 1568: Impaired antigen presentation Dec 25, 2018 Dec 25, 2018 None
1826 1573: Suppressed MyD88 986: Impairment of TDAR Jan 6, 2019 Jan 6, 2019 None
1870 1573: Suppressed MyD88 202: Inhibition, Nuclear factor kappa B (NF-kB) Mar 12, 2019 Mar 12, 2019 None
1818 1566: Suppressed NF-kB 1567: Suppressed DC activation Dec 25, 2018 Dec 25, 2018 None
2001 1702: Suppression of T cell activation 202: Inhibition, Nuclear factor kappa B (NF-kB) Nov 17, 2019 Nov 17, 2019 None
2004 1702: Suppression of T cell activation 986: Impairment of TDAR Nov 17, 2019 Mar 2, 2023 None
2927 1702: Suppression of T cell activation 1700: Impaired IL-1R1 signaling May 24, 2023 May 24, 2023 None
2928 1702: Suppression of T cell activation 984: Impairment, T-cell dependent antibody response May 24, 2023 May 25, 2023
2027 1718: Suppression of IL-4 production 1719: Impairment, TDAR Jan 5, 2020 Apr 4, 2021
2026 1717: Suppression of STAT5 binding to cytokine gene promoters 1718: Suppression of IL-4 production Jan 5, 2020 Mar 30, 2021
476 456: Suppression, Constitutive androstane receptor, NR1l3 167: Activation, LXR Nov 29, 2016 Dec 3, 2016
477 456: Suppression, Constitutive androstane receptor, NR1l3 228: demethylation, PPARg promoter Nov 29, 2016 Dec 3, 2016
1086 1046: Suppression, Estrogen receptor (ER) activity 1056: Decrease, E2 blood concentrations at hypothalamus Nov 29, 2016 Dec 3, 2016