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All KERs

Showing 326 to 350 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1653	1469: TGFbeta pathway activation	1457: EMT	Aug 16, 2017	Aug 16, 2017	1 AOP 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
301	272: Activation/Proliferation, T-cells	312: N/A, Allergic contact dermatitis on challenge	Nov 29, 2016	Dec 3, 2016	None
835	272: Activation/Proliferation, T-cells	827: sensitisation, skin	Nov 29, 2016	Dec 3, 2016	1 AOP 40: Covalent Protein binding leading to Skin Sensitisation
1701	272: Activation/Proliferation, T-cells	313: Increase, Allergic Respiratory Hypersensitivity Response	Dec 7, 2017	Aug 1, 2022	1 AOP 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
2157	1793: AP-1 activation	1795: TGFbeta expression	Jul 9, 2020	Jul 9, 2020	1 AOP 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
2523	1937: ADAM17 induction	1938: ACE2 increased shedding	Oct 28, 2021	Oct 28, 2021	None
2696	2025: Affected folate transporter	2026: decrease folate	Jul 19, 2022	Jul 19, 2022	1 AOP 449: Ceramide synthase inhibition leading to neural tube defects
31	25: Agonism, Androgen receptor	129: Reduction, Gonadotropins, circulating concentrations	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
32	25: Agonism, Androgen receptor	274: Reduction, Testosterone synthesis by ovarian theca cells	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
1384	25: Agonism, Androgen receptor	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Mar 17, 2017	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
1385	25: Agonism, Androgen receptor	285: Reduction, Vitellogenin synthesis in liver	Mar 17, 2017	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
2260	25: Agonism, Androgen receptor	1790: Increased, Differentiation to Testis	Jan 12, 2021	Jan 3, 2023	1 AOP 376: Androgen receptor agonism leading to male-biased sex ratio
2349	25: Agonism, Androgen receptor	1791: Increased, Male Biased Sex Ratio	Apr 12, 2021	Jan 3, 2023	1 AOP 376: Androgen receptor agonism leading to male-biased sex ratio
2918	25: Agonism, Androgen receptor	2143: Increased, gene expression of AR	May 22, 2023	May 22, 2023	1 AOP 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
2926	25: Agonism, Androgen receptor	2139: Reduction, the ratio of E2/11-KT in plasma	May 22, 2023	May 22, 2023	1 AOP 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
126	111: Agonism, Estrogen receptor	363: Altered, Reproductive behaviour	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
127	111: Agonism, Estrogen receptor	364: Impaired development of, Reproductive organs	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
128	111: Agonism, Estrogen receptor	307: Increase, Vitellogenin synthesis in liver	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
2626	1984: Agonism, Estrogen Receptor alpha	1985: Increased, Kisspeptin signalling	Apr 5, 2022	Apr 11, 2022	None
2628	1984: Agonism, Estrogen Receptor alpha	1986: Decreased, Gonadotropins	Apr 5, 2022	Apr 5, 2022	None
3109	2201: RAR agonism	2202: Altered expression of cell cycle genes	Jan 14, 2024	Apr 18, 2024	2 AOPs 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
3113	2201: RAR agonism	2203: Decreased proliferation of cortical NPCs	Jan 14, 2024	Feb 14, 2024	2 AOPs 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
3114	2201: RAR agonism	341: Impairment, Learning and memory	Jan 14, 2024	Jan 14, 2024	1 AOP 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory
3128	2201: RAR agonism	2211: Microcephalus	Feb 2, 2024	Feb 2, 2024	None
3144	2201: RAR agonism	1978: Microcephaly	Mar 13, 2024	Mar 13, 2024	1 AOP 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly

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