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Showing 801 to 825 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

729	742: Decreased, Androgen receptor activity	743: Decreased, Testosterone binding to androgen receptor (hypothalamus)	Nov 29, 2016	Dec 3, 2016	1 AOP 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
1542	1409: Decreased, angiogenesis	1385: Activated, gastric ulcer formation	Jun 2, 2017	Jun 2, 2017	1 AOP 228: NSAID induced PTGS2 inactivation to gastric ulcer
645	627: Decreased, anxiety	629: Decreased, sheltering	Nov 29, 2016	Dec 3, 2016	1 AOP 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
1248	1183: Decreased, Apoptosis (Epithelial Cells)	1192: Increased, Ductal Hyperplasia	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
2914	1183: Decreased, Apoptosis (Epithelial Cells)	854: Alterations, Cellular proliferation / hyperplasia	May 11, 2023	May 11, 2023	1 AOP 495: Androgen receptor activation leading to prostate cancer
801	800: Decreased, Aromatase (Cyp19a1) mRNA	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Nov 29, 2016	Dec 3, 2016	2 AOPs 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
2870	2123: decreased, Bcl-2	55: Cell injury/death	Apr 4, 2023	Apr 4, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
2873	2123: decreased, Bcl-2	1825: Increase, Cell death	Apr 4, 2023	Apr 4, 2023	None
1540	1407: Decreased, bicarbonate	1405: Reduced, mucosal defense	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
1101	1058: Decreased, bile flow	1059: Increased, cholestasis	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
62	52: Decreased, Calcium influx	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	None
347	52: Decreased, Calcium influx	381: BDNF, Reduced	Nov 29, 2016	Jun 13, 2018	2 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
3167	656: Decreased COUP-TFII in Leydig cells	647: Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes	Mar 20, 2024	Apr 16, 2024	2 AOPs 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
2072	807: Decreased, cholesterol	1756: Decreased, 11KT	Mar 23, 2020	May 6, 2020	1 AOP 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
3201	807: Decreased, cholesterol	1690: Decrease, testosterone levels	Apr 25, 2024	Apr 25, 2024	1 AOP 124: HMG-CoA reductase inhibition leading to decreased fertility
537	482: Decreased, DHB4/HSD17B4	451: Inhibition, Mitochondrial fatty acid beta-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
1121	1083: Decreased, Dopaminergic activity	1084: Increased, prolactin secretion	Nov 29, 2016	Dec 3, 2016	1 AOP 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1435	1347: Decreased, extracellular serotonin	1326: Increased, 5-HT3	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1436	1347: Decreased, extracellular serotonin	1328: Inactivated, 5-HTR	Apr 14, 2017	Apr 14, 2017	5 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression
1437	1347: Decreased, extracellular serotonin	1336: Activation, 5-HT2A	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1519	1347: Decreased, extracellular serotonin	1325: Decreased, synaptic release	May 30, 2017	May 30, 2017	None
2377	1878: Decreased, Eye size	1643: Altered, Visual function	May 11, 2021	Jan 7, 2022	2 AOPs 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size
2406	1878: Decreased, Eye size	351: Increased Mortality	May 28, 2021	May 28, 2021	None
1552	1414: Decreased, GABA	1415: Reduced, GABA-A receptor activation	Jun 2, 2017	Jun 2, 2017	1 AOP 231: presynaptic neuron 2 repression to epilepsy
1245	1179: Decreased, GABA release	1178: Decreased, Chloride conductance	Nov 29, 2016	Dec 3, 2016	None

Key Event Relationships (KERs)

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