AOP-Wiki

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All KERs

Showing 1476 to 1500 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2592	1634: Increase, Oxidative DNA damage	1775: Increase, Oocyte apoptosis	Mar 1, 2022	Mar 1, 2022	1 AOP 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
1877	1608: Increase,Oxidative DNA damage	1365: Increase, Apoptosis	Mar 19, 2019	Mar 19, 2019	1 AOP 325: Thermal stress leading to population decline (2)
2190	1608: Increase,Oxidative DNA damage	1262: Apoptosis	Nov 2, 2020	Nov 2, 2020	None
2221	1608: Increase,Oxidative DNA damage	1825: Increase, Cell death	Dec 4, 2020	Dec 4, 2020	None
2558	1608: Increase,Oxidative DNA damage	1775: Increase, Oocyte apoptosis	Feb 4, 2022	Feb 4, 2022	None
2559	1608: Increase,Oxidative DNA damage	1776: Increase, Ovarian somatic cell apoptosis	Feb 4, 2022	Feb 4, 2022	None
3095	1608: Increase,Oxidative DNA damage	1461: Increase, DSB	Nov 16, 2023	Nov 16, 2023	1 AOP 330: Excessive reactive oxygen species production leading to mortality (4)
763	769: Increase, Oxidative metabolism	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
2897	1969: Increase, Oxidative Stress	277: TH synthesis, Decreased	Apr 24, 2023	May 23, 2023	2 AOPs 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
2980	1969: Increase, Oxidative Stress	2009: Activation, inflammation pathway	Aug 19, 2023	Aug 19, 2023	2 AOPs 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2993	1969: Increase, Oxidative Stress	2166: Abnormal expression of NO	Aug 20, 2023	Aug 20, 2023	1 AOP 510: Demethylation of PPAR promotor leading to vascular disrupting effects
2999	1969: Increase, Oxidative Stress	2170: Activated ANG/Tie2 pathway	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3000	1969: Increase, Oxidative Stress	2164: Activation, Dll4-Notch pathway	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3001	1969: Increase, Oxidative Stress	2171: Activated BMP/TGF-beta pathway	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3002	1969: Increase, Oxidative Stress	2172: Activated Wnt/Frizzled pathway	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3003	1969: Increase, Oxidative Stress	932: Uncoupling, eNOS	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3004	1969: Increase, Oxidative Stress	2173: Activated AKT/ERK/PI3K pathway	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3005	1969: Increase, Oxidative Stress	2174: Inhibition VEGF/VEGFR pathway	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3033	1969: Increase, Oxidative Stress	1365: Increase, Apoptosis	Aug 28, 2023	Aug 28, 2023	1 AOP 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
3130	1969: Increase, Oxidative Stress	177: Mitochondrial dysfunction	Feb 21, 2024	Feb 21, 2024	3 AOPs 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
1362	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	1281: Increased, DNA Damage-Repair	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1364	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	1280: Activation, HIF-1	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
3166	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	177: Mitochondrial dysfunction	Mar 14, 2024	Mar 14, 2024	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
2220	1826: Increase, Oxygen consumption	257: Increase, ROS production	Dec 4, 2020	Dec 4, 2020	None
2340	1865: Increase, OEC damage	1862: Decrease, Photosystem II efficiency	Apr 11, 2021	Apr 11, 2021	1 AOP 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis

Key Event Relationships (KERs)

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