Key Event Relationships (KERs)

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Showing 1776 to 1800 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1862 389: Increased, Intracellular Calcium overload 55: Cell injury/death Feb 19, 2019 Sep 3, 2023
2140 389: Increased, Intracellular Calcium overload 1788: Status epilepticus May 21, 2020 May 21, 2020 None
2704 389: Increased, Intracellular Calcium overload 2038: Activation, calpain Jul 25, 2022 Jul 25, 2022
2709 389: Increased, Intracellular Calcium overload 1477: Decrease, OXPHOS Jul 25, 2022 Jul 25, 2022 None
2710 389: Increased, Intracellular Calcium overload 2017: Endoplasmic reticulum stress Jul 25, 2022 Jul 25, 2022
3042 389: Increased, Intracellular Calcium overload 1816: Mitochondrial dysfunction EMPTY Sep 14, 2023 Sep 14, 2023 None
3091 389: Increased, Intracellular Calcium overload 2078: Loss of drebrin Oct 18, 2023 Oct 18, 2023
1465 1322: Increased, intracellular chloride (Cl-) 1356: Inactive, membrane depolarization Apr 14, 2017 Apr 14, 2017
1525 1398: Increased, intracellular serotonin 1399: Increased, packaged serotonin Jun 1, 2017 Jun 1, 2017
1455 1321: Increased, intracellular sodium (Na+) 1352: Activated, voltage-gated sodium channel Apr 14, 2017 Apr 14, 2017
2576 1196: Increased, Invasion 1193: N/A, Breast Cancer Feb 15, 2022 Feb 15, 2022 None
3138 1196: Increased, Invasion 1982: Metastasis, Breast Cancer Mar 5, 2024 Mar 5, 2024
2462 759: Increased, Kidney Failure 350: Increase, Mortality Aug 5, 2021 Aug 5, 2021 None
2466 759: Increased, Kidney Failure 351: Increased Mortality Aug 11, 2021 Aug 11, 2021
2627 1985: Increased, Kisspeptin signalling 1986: Decreased, Gonadotropins Apr 5, 2022 Aug 15, 2022
1120 1081: Increased, lactotroph hyperplasia and hypertrophy 1082: Increased, adenomas (pituitary) Nov 29, 2016 Dec 3, 2016
1117 1080: Increased, latency period 1079: Increased, Adenomas/carcinomas (mammary) Nov 29, 2016 Dec 3, 2016
508 467: Increased, LDL uptake 327: Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
1545 1411: Increased, leukocyte activation 1385: Activated, gastric ulcer formation Jun 2, 2017 Jun 2, 2017
1544 1410: Increased, leukocyte adherence 1411: Increased, leukocyte activation Jun 2, 2017 Jun 2, 2017
794 791: Increased, Leutinizing hormone (LH) 744: Increase, Hyperplasia (Leydig cells) Nov 29, 2016 Dec 3, 2016
1599 1445: Increased, LPO 1446: Decrease, Coupling of OXPHOS Jun 29, 2017 Jun 29, 2017 None
2097 1445: Increased, LPO 1772: Decrease, Neutral lipids Apr 30, 2020 Apr 30, 2020
2210 1445: Increased, LPO 1365: Increase, Apoptosis Nov 25, 2020 Nov 25, 2020 None
2222 1445: Increased, LPO 1825: Increase, Cell death Dec 4, 2020 Dec 4, 2020 None