| 2490 |
1931: Disruption of the intestinal barrier |
1497: Recruitment of inflammatory cells |
Oct 19, 2021 |
Oct 19, 2021 |
None
|
| 2494 |
1931: Disruption of the intestinal barrier |
1932: GI disorders |
Oct 19, 2021 |
Oct 19, 2021 |
None
|
| 2495 |
1931: Disruption of the intestinal barrier |
1868: Hyperinflammation |
Oct 19, 2021 |
Feb 8, 2023 |
None
|
| 393 |
405: irregularities, ovarian cycle |
330: Decrease, Fertility |
Nov 29, 2016 |
Dec 3, 2016 |
None
|
| 394 |
405: irregularities, ovarian cycle |
406: impaired, Fertility |
Nov 29, 2016 |
Dec 3, 2016 |
3 AOPs
|
| 1167 |
1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle |
1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carbo |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 1774 |
1434: Irritation induced sneezing |
1223: Increased Airway Hyper-responsiveness,Cough, Dyspnea |
Sep 24, 2018 |
Sep 24, 2018 |
None
|
| 955 |
927: S-Glutathionylation, eNOS |
932: Uncoupling, eNOS |
Nov 29, 2016 |
Oct 12, 2017 |
1 AOP
|
| 952 |
935: Decrease, GTPCH-1 |
934: Decrease, Tetrahydrobiopterin |
Nov 29, 2016 |
Oct 12, 2017 |
1 AOP
|
| 953 |
934: Decrease, Tetrahydrobiopterin |
932: Uncoupling, eNOS |
Nov 29, 2016 |
Oct 12, 2017 |
1 AOP
|
| 956 |
932: Uncoupling, eNOS |
933: Depletion, Nitric Oxide |
Nov 29, 2016 |
Oct 12, 2017 |
1 AOP
|
| 3014 |
932: Uncoupling, eNOS |
2161: Increase, Vascular disrupting effects |
Aug 21, 2023 |
Aug 21, 2023 |
None
|
| 3023 |
932: Uncoupling, eNOS |
1928: increased，Vascular endothelial dysfunction |
Aug 21, 2023 |
Aug 21, 2023 |
1 AOP
|
| 988 |
973: Decrease, AKT/eNOS activity |
933: Depletion, Nitric Oxide |
Nov 29, 2016 |
Oct 16, 2017 |
1 AOP
|
| 958 |
933: Depletion, Nitric Oxide |
937: Impaired, Vasodilation |
Nov 29, 2016 |
Oct 12, 2017 |
1 AOP
|
| 982 |
937: Impaired, Vasodilation |
951: Increase, Vascular Resistance |
Nov 29, 2016 |
Oct 13, 2017 |
1 AOP
|
| 983 |
951: Increase, Vascular Resistance |
952: Hypertension |
Nov 29, 2016 |
Oct 13, 2017 |
1 AOP
|
| 2152 |
1795: TGFbeta expression |
1283: Activation, TGF-beta pathway |
Jul 9, 2020 |
Jul 9, 2020 |
1 AOP
|
| 1778 |
1494: Leukocyte recruitment/activation |
265: Activation, Stellate cells |
Nov 12, 2018 |
Nov 12, 2018 |
1 AOP
|
| 1901 |
1494: Leukocyte recruitment/activation |
1182: Increase, Cell Proliferation (Epithelial Cells) |
May 7, 2019 |
May 7, 2019 |
None
|
| 1905 |
1494: Leukocyte recruitment/activation |
1632: Increase in RONS |
May 7, 2019 |
May 9, 2019 |
2 AOPs
|
| 2891 |
1494: Leukocyte recruitment/activation |
1501: Increased extracellular matrix deposition |
Apr 13, 2023 |
Apr 13, 2023 |
1 AOP
|
| 1728 |
1511: Lipid Peroxidation |
1509: Protein Adduct Formation |
Apr 4, 2018 |
Apr 5, 2018 |
1 AOP
|
| 1731 |
1511: Lipid Peroxidation |
1513: General Apoptosis |
Apr 4, 2018 |
Apr 5, 2018 |
1 AOP
|
| 1500 |
1389: Locomotor activity, decreased |
1141: Decreased, Reproductive Success |
May 8, 2017 |
Jun 26, 2017 |
1 AOP
|