Key Event Relationships (KERs)

API

Fulltext search has been disabled for Key Event Relationships (KERs) at this time. If you need this feature, send an email to aopwiki@googlegroups.com

Queries Key Event Relationship (KER) titles
Filter by Upstream Key Event title
Filter by Downstream Key Event title
Filter by AOP title
Clear All Filters

Showing 2426 to 2450 of 2767 KERs

Clear Table Filters
ID Upstream Event Downstream Event Creation Date Last Updated AOPs
395 228: demethylation, PPARg promoter 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Nov 29, 2016 Dec 3, 2016 None
411 228: demethylation, PPARg promoter 54: Up Regulation, CD36 Nov 29, 2016 Nov 29, 2016
487 228: demethylation, PPARg promoter 457: Activation, SREBF1 Nov 29, 2016 Dec 3, 2016
1402 228: demethylation, PPARg promoter 1301: Activation, SREBP-1 Apr 12, 2017 Apr 12, 2017 None
1424 228: demethylation, PPARg promoter 116: Activation, FAS Apr 13, 2017 Apr 13, 2017 None
1608 228: demethylation, PPARg promoter 1028: Activation of specific nuclear receptors, PPAR-gamma activation Jul 24, 2017 Jul 24, 2017
1659 228: demethylation, PPARg promoter 465: Increased, FA Influx Aug 31, 2017 Aug 31, 2017
2988 228: demethylation, PPARg promoter 2165: Activation of PPAR Aug 20, 2023 Aug 20, 2023
1125 1086: persistent, cytotoxicity (pleura or peritoneum) 1087: Increased, inflammation Nov 29, 2016 Dec 3, 2016
1126 1086: persistent, cytotoxicity (pleura or peritoneum) 1088: Increased, Oxidative Stress Nov 29, 2016 Dec 3, 2016
1377 1289: Perturbation of cholesterol 1291: Hepatotoxicity Feb 15, 2017 Feb 15, 2017
2151 1794: Pin-1 activation 1795: TGFbeta expression Jul 9, 2020 Jul 9, 2020
2456 1914: Platelet activation, Increased 1857: Platelet-neutrophil interactions, Increased Aug 4, 2021 Aug 4, 2021
2458 1857: Platelet-neutrophil interactions, Increased 1916: Thromboinflammation, Increased Aug 4, 2021 Aug 4, 2021
2070 1754: Porcupine-induced Wnt secretion and Wnt signaling activation 1755: beta-catenin activation Mar 23, 2020 Nov 9, 2021
2607 1979: Premature differentiation 1978: Microcephaly Mar 21, 2022 Mar 21, 2022 None
3107 1979: Premature differentiation 2200: decline, neural progenitor cells Jan 10, 2024 Jan 10, 2024
1211 1146: premature, Spawning 1164: Increased, Population Nov 29, 2016 Dec 3, 2016 None
1222 1146: premature, Spawning 1141: Decreased, Reproductive Success Nov 29, 2016 Dec 3, 2016 None
1179 1144: premature, spawning 1 1141: Decreased, Reproductive Success Nov 29, 2016 Dec 3, 2016 None
1102 1064: prepubertal increase, Estrogen receptor (ER) activity 1065: Activation, estrogen receptor alpha Nov 29, 2016 Dec 3, 2016
1283 1234: Production of nerve growth factor , Epithelial irritation 1222: SP (Substance P) release, Local increase of SP Nov 29, 2016 Dec 3, 2016 None
1358 1274: Production of α-smooth muscle actin 1276: Lung fibrosis Feb 15, 2017 Feb 15, 2017 None
93 77: Production, Critical Metabolites (CGA 330050 and CGA 265307) 164: Induction, Liver “Dysfunctional” Changes by CGA 330050 Nov 29, 2016 Dec 3, 2016
276 249: Production, Reactive oxygen species 209: Peptide Oxidation Nov 29, 2016 Dec 3, 2016