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Showing 726 to 750 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2334	1475: Decrease, Photosynthesis	1472: Decrease, ATP production	Apr 11, 2021	Apr 11, 2021	2 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
2343	1475: Decrease, Photosynthesis	1808: Decrease, ATP synthase activity	Apr 11, 2021	Apr 11, 2021	None
1737	1517: Decrease, PSII activity	1475: Decrease, Photosynthesis	May 24, 2018	May 24, 2018	None
1740	1517: Decrease, PSII activity	1364: Increase, ROS	May 24, 2018	May 24, 2018	None
2333	1862: Decrease, Photosystem II efficiency	1475: Decrease, Photosynthesis	Apr 11, 2021	Apr 11, 2021	2 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
2180	1810: Decrease, ATPase activity	1768: Increase, Abnormal osmoregulation	Nov 2, 2020	Nov 2, 2020	None
2756	2061: Decrease, Prevent chitin degradation by chitinases	2062: Weak, Procuticle protection	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
2336	1863: Decrease, Reproduction	360: Decrease, Population growth rate	Apr 11, 2021	Apr 11, 2021	5 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2556	1863: Decrease, Reproduction	442: Decreased, Population trajectory	Jan 21, 2022	Jan 21, 2022	1 AOP 435: Deposition of ionising energy leads to population decline via pollen abnormal
769	771: Decrease, Serum thyroid hormone (T4/T3)	753: Increase, Thyroid-stimulating hormone (TSH)	Nov 29, 2016	Dec 3, 2016	None
2735	2044: Decrease, SMO relocation	2028: Decrease, GLI1/2 translocation	Aug 23, 2022	May 22, 2023	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
2732	2043: Decrease, SHH second messenger production	1821: Decrease, Cell proliferation	Aug 23, 2022	Nov 14, 2023	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
2733	2043: Decrease, SHH second messenger production	1365: Increase, Apoptosis	Aug 23, 2022	Aug 23, 2022	None
2957	2043: Decrease, SHH second messenger production	1262: Apoptosis	Jun 29, 2023	Jun 29, 2023	1 AOP 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
3060	2197: Decrease, sox10	352: N/A, Neurodegeneration	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
2685	2020: Decrease, sox9 expression	1559: Smaller and morphologically distorted facial cartilage structures	Jun 30, 2022	Oct 20, 2022	1 AOP 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
2691	2020: Decrease, sox9 expression	317: Altered, Cardiovascular development/function	Jun 30, 2022	Oct 20, 2022	1 AOP 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
436	266: Decrease, Steroidogenic acute regulatory protein (STAR)	447: Reduction, Cholesterol transport in mitochondria	Nov 29, 2016	Dec 2, 2016	1 AOP 18: PPARα activation in utero leading to impaired fertility in males
1547	1382: Decrease, surfactant	1405: Reduced, mucosal defense	Jun 2, 2017	Jun 2, 2017	1 AOP 229: Helicobacter pylori to gastric ulcer
2126	1690: Decrease, testosterone levels	1613: Decrease, DHT level	May 11, 2020	Oct 19, 2023	2 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
2131	1690: Decrease, testosterone levels	1614: Decrease, AR activation	May 11, 2020	Apr 5, 2024	2 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
3169	1690: Decrease, testosterone levels	2212: Epididymal agenesis	Mar 20, 2024	Apr 8, 2024	1 AOP 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
3202	1690: Decrease, testosterone levels	809: malformed, Male reproductive tract	Apr 25, 2024	Apr 25, 2024	1 AOP 124: HMG-CoA reductase inhibition leading to decreased fertility
3205	1690: Decrease, testosterone levels	348: Malformation, Male reproductive tract	May 1, 2024	May 1, 2024	1 AOP 18: PPARα activation in utero leading to impaired fertility in males
3206	1690: Decrease, testosterone levels	414: Increase, Luteinizing hormone (LH)	May 1, 2024	May 1, 2024	1 AOP 51: PPARα activation leading to impaired fertility in adult male rodents

Key Event Relationships (KERs)

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