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All KERs

Showing 876 to 900 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

260	233: Decreased, PPAR-gamma activation	140: Decreased, HSD17B10 expression	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
3093	233: Decreased, PPAR-gamma activation	1060: Alteration, lipid metabolism	Oct 18, 2023	Oct 19, 2023	1 AOP 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
878	858: Decreased, PPARalpha transactivation of gene expression	859: Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids	Nov 29, 2016	Jun 2, 2017	None
879	858: Decreased, PPARalpha transactivation of gene expression	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	Nov 29, 2016	Jun 2, 2017	None
880	858: Decreased, PPARalpha transactivation of gene expression	861: Decreased, Ketogenesis (production of ketone bodies)	Nov 29, 2016	Jun 11, 2018	1 AOP 6: Antagonist binding to PPARα leading to body-weight loss
1748	858: Decreased, PPARalpha transactivation of gene expression	1528: Fatty Acid Beta Oxidation, Decreased	Jun 11, 2018	Jun 11, 2018	1 AOP 6: Antagonist binding to PPARα leading to body-weight loss
772	749: Decreased, Progesterone from corpus luteum	772: Increase, Hyperplasia (glandular epithelial cells of endometrium)	Nov 29, 2016	Dec 3, 2016	1 AOP 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
733	747: Decreased, Prolactin	748: Increased, Estrogen receptor (ER) activity	Nov 29, 2016	Dec 3, 2016	1 AOP 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
1138	1104: Decreased, Prostaglandin F2alpha concentration, plasma	1105: Occurrence, renal ischemia	Nov 29, 2016	Dec 3, 2016	1 AOP 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
682	681: Decreased, Prostaglandin F2alpha synthesis, ovary	671: Reduced, Prostaglandin F2alpha concentration, plasma	Nov 29, 2016	Dec 3, 2016	1 AOP 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
832	825: Decreased, Renal ability to dilute urine	814: Occurrence, Kidney toxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 128: Kidney dysfunction by decreased thyroid hormone
830	820: Decreased, Renal plasma flow	814: Occurrence, Kidney toxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 128: Kidney dysfunction by decreased thyroid hormone
2635	1141: Decreased, Reproductive Success	360: Decrease, Population growth rate	Apr 6, 2022	Apr 6, 2022	3 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1426	1317: Decreased, serotonin transporter activity	1321: Increased, intracellular sodium (Na+)	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1427	1317: Decreased, serotonin transporter activity	1322: Increased, intracellular chloride (Cl-)	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1428	1317: Decreased, serotonin transporter activity	1318: Decreased, extracellular Na+	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1429	1317: Decreased, serotonin transporter activity	1319: Decreased, extracellular chloride (Cl-)	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1430	1317: Decreased, serotonin transporter activity	1320: Increased, extracellular serotonin	Apr 14, 2017	Apr 14, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1431	1317: Decreased, serotonin transporter activity	1323: Decreased, intracellular serotonin	Apr 14, 2017	Apr 14, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1065	1022: Decreased, serum T4/T3	1023: Increased, Thyroid-stimulating hormone (TSH)	Nov 29, 2016	Dec 3, 2016	None
646	629: Decreased, sheltering	588: Increased, predation	Nov 29, 2016	Dec 3, 2016	1 AOP 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
586	585: Decreased, Sodium conductance 1	586: Reduced, swimming speed	Nov 29, 2016	Dec 3, 2016	3 AOPs 91: Sodium channel inhibition leading to reduced survival 93: sodium channel inhibition leading to increased predation 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
594	585: Decreased, Sodium conductance 1	444: Increased, Atrioventricular block and bradycardia	Nov 29, 2016	Dec 3, 2016	1 AOP 94: Sodium channel inhibition leading to congenital malformations
1243	1176: Decreased, sodium conductance 2	1177: Decreased, Ionotropic GABA receptor chloride channel conductance	Nov 29, 2016	Dec 3, 2016	None
1244	1176: Decreased, sodium conductance 2	1179: Decreased, GABA release	Nov 29, 2016	Dec 3, 2016	1 AOP 197: Sodium channel (Nav1.1) inhibition leading to population decline

Key Event Relationships (KERs)

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