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Showing 1026 to 1050 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2006	1703: Cardiovascular dysregulation	445: Respiratory distress/arrest	Nov 25, 2019	Dec 19, 2019	1 AOP 16: Acetylcholinesterase inhibition leading to acute mortality
3223	2224: Dysregulation of transcriptional expression within PPAR signaling network	179: Decreased, Mitochondrial fatty acid beta-oxidation	May 14, 2024	May 24, 2024	1 AOP 529: Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
3224	2224: Dysregulation of transcriptional expression within PPAR signaling network	2225: Disrupted Lipid Storage	May 14, 2024	May 23, 2024	1 AOP 529: Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
2493	1854: ACE2 dysregulation	1497: Recruitment of inflammatory cells	Oct 19, 2021	Oct 19, 2021	None
2532	1854: ACE2 dysregulation	1954: Gut dysbiosis	Dec 2, 2021	Dec 2, 2021	1 AOP 428: Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis
2831	1854: ACE2 dysregulation	2096: (Micro)vascular dysfunction	Jan 23, 2023	Feb 28, 2023	1 AOP 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
1856	1600: Eczematous eruption	1601: Scaling, Lichenification	Feb 4, 2019	Feb 4, 2019	None
2680	2011: Emphysema	2008: Chronic obstructive pulmonary disease	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
1775	1539: Endocytosis	898: Disruption, Lysosome	Nov 12, 2018	Nov 12, 2018	2 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
2711	2017: Endoplasmic reticulum stress	1512: Unfolded Protein Response	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2453	1913: Endothelial cell dysfunction	87: Release, Cytokine	Aug 4, 2021	Aug 4, 2021	1 AOP 412: Endothelial cell dysfunction leading to thromboinflammation
2511	1913: Endothelial cell dysfunction	1666: dysfunction of microcirculation	Oct 28, 2021	Oct 28, 2021	None
3170	2212: Epididymal agenesis	1758: Impaired, Spermatogenesis	Mar 20, 2024	Apr 8, 2024	1 AOP 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
2970	2152: Epigenetic modification process	2153: Expression of factors ruling proliferation, modified	Jul 27, 2023	Jul 27, 2023	1 AOP 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
1627	1457: EMT	1273: Expression of Collagen	Jul 26, 2017	Jul 26, 2017	None
1655	1457: EMT	68: Accumulation, Collagen	Aug 16, 2017	Aug 16, 2017	1 AOP 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
1725	1457: EMT	1276: Lung fibrosis	Mar 18, 2018	Mar 18, 2018	None
1779	1457: EMT	1275: Collagen Deposition	Nov 20, 2018	Nov 20, 2018	1 AOP 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
1840	1457: EMT	1587: Fibroproliferative airway lesions	Jan 30, 2019	Jan 30, 2019	1 AOP 280: α-diketone-induced bronchiolitis obliterans
2154	1457: EMT	1458: Pulmonary fibrosis	Jul 9, 2020	Jul 9, 2020	1 AOP 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
2614	1457: EMT	1982: Metastasis, Breast Cancer	Mar 22, 2022	Sep 26, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
3200	1457: EMT	1651: Resistant gastric cancer	Apr 23, 2024	Apr 23, 2024	1 AOP 298: Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
3204	1457: EMT	2013: Airway remodeling	May 1, 2024	May 1, 2024	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
2880	2126: ERa inactivation	2127: Increased adipocyte size	Apr 6, 2023	Apr 6, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2881	2126: ERa inactivation	2128: Increased adipocyte numbers	Apr 6, 2023	Apr 6, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity

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