Key Event Relationships (KERs)

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Showing 1651 to 1675 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2545 1847: SARS-CoV-2 production 1870: Sustentacular cells, decrease Jan 5, 2022 Jan 5, 2022
2546 1847: SARS-CoV-2 production 1931: Disruption of the intestinal barrier Jan 5, 2022 Jun 14, 2022
2329 1855: Increased Sodium-sensitive hypertension 1603: Chronic kidney disease Apr 10, 2021 Apr 10, 2021
2698 2033: Increased S1-P 1502: Histone deacetylase inhibition Jul 19, 2022 Jul 19, 2022
1592 1441: Systemic cholesterol increased 1442: Foam cell formation Jun 29, 2017 Jun 29, 2017 None
2315 1858: Increased viral transcription and replication 1496: Increased proinflammatory mediators Apr 9, 2021 Apr 9, 2021 None
2316 1858: Increased viral transcription and replication 1848: TLR Activation/Dysregulation Apr 9, 2021 Apr 9, 2021 None
1445 1326: Increased, 5-HT3 1344: Increased, seizure Apr 14, 2017 Apr 14, 2017
707 708: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) 709: Increase, Cytotoxicity (renal tubular cell) Nov 29, 2016 Dec 3, 2016
146 134: Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) 209: Peptide Oxidation Nov 29, 2016 Dec 3, 2016 None
147 134: Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) 276: Up Regulation, TGFbeta1 expression Nov 29, 2016 Nov 29, 2016 None
3236 2231: Increased, activation of RAAS 2230: Increased, afferent artery vasoconstriction Jun 6, 2024 Jun 6, 2024 None
1706 1499: Activation of Th2 cells 1500: Increased cellular proliferation and differentiation Jan 5, 2018 May 18, 2023
1073 1029: Increased, adipogenesis 1032: Increased, secretion of local growth factors Nov 29, 2016 Dec 3, 2016
3235 2230: Increased, afferent artery vasoconstriction 819: Decreased, Glomerular filtration Jun 6, 2024 Jun 6, 2024
3255 2241: Increased, AP-1 activity 2242: Increased, edn1 gene expression Jun 20, 2024 Jun 20, 2024
568 574: Increased, Appetite and hunger 560: Abnormal, Foraging activity and behavior Nov 29, 2016 Dec 3, 2016
607 602: Increased, Ataxia, paralysis, or hyperactivity 351: Increased Mortality Nov 29, 2016 Dec 3, 2016
432 444: Increased, Atrioventricular block and bradycardia 351: Increased Mortality Nov 29, 2016 Nov 29, 2016 None
591 444: Increased, Atrioventricular block and bradycardia 445: Respiratory distress/arrest Nov 29, 2016 Dec 3, 2016
2871 2124: increased, Bax 55: Cell injury/death Apr 4, 2023 Apr 4, 2023
2874 2124: increased, Bax 1825: Increase, Cell death Apr 4, 2023 Apr 4, 2023 None
706 714: Increased, Binding of chemicals to 2u (serum) 708: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) Nov 29, 2016 Dec 3, 2016
1135 1098: Increased, blood potassium concentration 1100: Occurrence, cardiac arrthymia Nov 29, 2016 Dec 3, 2016 None
1140 1098: Increased, blood potassium concentration 1106: Occurrence, cardiac arrhythmia Nov 29, 2016 Dec 3, 2016