Key Event Relationships (KERs)

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Showing 1951 to 1975 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2855 1919: Increased，Cardiac dysfunction 351: Increased Mortality Jan 29, 2023 Jan 29, 2023 None
2526 1940: Increases in cellular ROS 1754: Porcupine-induced Wnt secretion and Wnt signaling activation Oct 31, 2021 Apr 27, 2022
1622 1455: Sustained inflammatory cytokine release 1032: Increased, secretion of local growth factors Jul 26, 2017 Jul 26, 2017 None
1633 1455: Sustained inflammatory cytokine release 1456: Differentiation of fibroblasts Jul 26, 2017 Jul 26, 2017 None
2065 1740: ACE2 enzymatic inhibition 1752: Increased AngII Mar 17, 2020 Mar 17, 2020
2321 1740: ACE2 enzymatic inhibition 1741: Induced, Angiotensin (Ang) II accumulation Apr 10, 2021 Apr 10, 2021 None
2434 1740: ACE2 enzymatic inhibition 1743: Increase plasma Ang II Jul 13, 2021 Jul 13, 2021
1323 1257: Induced parturition 1141: Decreased, Reproductive Success Jan 13, 2017 Jan 13, 2017
1326 1257: Induced parturition 1163: Increased, Reproductive Success Jan 13, 2017 Jan 13, 2017
1324 1255: induced spawning 1141: Decreased, Reproductive Success Jan 13, 2017 Jan 13, 2017 None
1325 1255: induced spawning 1163: Increased, Reproductive Success Jan 13, 2017 Jan 13, 2017
2295 1741: Induced, Angiotensin (Ang) II accumulation 1849: Impaired gustatory nerve Mar 28, 2021 Mar 28, 2021 None
2322 1741: Induced, Angiotensin (Ang) II accumulation 1852: Increased Ang II type 1 receptor (AT1R) Apr 10, 2021 Apr 10, 2021 None
2520 1741: Induced, Angiotensin (Ang) II accumulation 1853: Hyperactivation of ACE/Ang-II/AT1R axis Oct 28, 2021 Oct 28, 2021 None
1961 1666: dysfunction of microcirculation 1667: anterior-posterior axis development Jul 3, 2019 Jul 3, 2019
2512 1666: dysfunction of microcirculation 1750: Increased inflammatory immune responses Oct 28, 2021 Oct 28, 2021 None
1221 1167: induced, parturition 1141: Decreased, Reproductive Success Nov 29, 2016 Dec 3, 2016 None
2021 1711: Induction of GATA3 expression 1712: Increase of Th2 cells producing IL-4 Dec 29, 2019 Aug 14, 2020
2538 1959: Induction of hERG trafficking defects 1960: Inhibition of Ikr Dec 13, 2021 Dec 13, 2021 None
1630 1459: Cell damage sensing 1455: Sustained inflammatory cytokine release Jul 26, 2017 Jul 26, 2017 None
1631 1459: Cell damage sensing 257: Increase, ROS production Jul 26, 2017 Jul 26, 2017 None
1632 1459: Cell damage sensing 1032: Increased, secretion of local growth factors Jul 26, 2017 Jul 26, 2017 None
70 60: Induction, Chitin degradation and resorption 238: Induction, Pre-mature molting Nov 29, 2016 Dec 3, 2016 None
868 850: Induction, CYP1A2/CYP1A5 844: Oxidation, Uroporphyrinogen Nov 29, 2016 May 31, 2018
2893 850: Induction, CYP1A2/CYP1A5 257: Increase, ROS production Apr 13, 2023 Apr 13, 2023 None