Key Event Relationships (KERs)

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Showing 2176 to 2200 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1705 1498: Loss of alveolar capillary membrane integrity 1499: Activation of Th2 cells Jan 5, 2018 May 16, 2023
2174 1498: Loss of alveolar capillary membrane integrity 1676: Blood extravasation into the lungs Oct 22, 2020 Oct 22, 2020 None
2258 1498: Loss of alveolar capillary membrane integrity 1833: Impaired lung function Jan 8, 2021 Jan 8, 2021 None
2259 1498: Loss of alveolar capillary membrane integrity 1671: Substance - LS interaction Jan 8, 2021 Jan 8, 2021 None
2368 1498: Loss of alveolar capillary membrane integrity 1672: Inhibition of LS function. Apr 27, 2021 Apr 27, 2021
2369 1498: Loss of alveolar capillary membrane integrity 1677: Reduced tidal volume Apr 27, 2021 Apr 27, 2021
2372 1498: Loss of alveolar capillary membrane integrity 1250: Decreased lung function Apr 27, 2021 Apr 27, 2021
1972 1675: Loss of barrier function 1676: Blood extravasation into the lungs Jul 3, 2019 Jul 3, 2019 None
2807 2078: Loss of drebrin 1944: Dysfunctional synapses Dec 11, 2022 Dec 11, 2022
3259 2245: LPS cell membrane integration, increased 2246: Oligodendrocyte death, increased Sep 6, 2024 Sep 26, 2024
3258 2244: LPS, increased 2245: LPS cell membrane integration, increased Sep 6, 2024 Sep 26, 2024
3263 2244: LPS, increased 149: Increase, Inflammation Sep 6, 2024 Sep 26, 2024
405 348: Malformation, Male reproductive tract 406: impaired, Fertility Nov 29, 2016 Dec 2, 2016
808 809: malformed, Male reproductive tract 330: Decrease, Fertility Nov 29, 2016 Dec 3, 2016
402 409: Metabolism of AFB1, Production of Reactive Electrophiles 373: Formation, Pro-mutagenic DNA Adducts Nov 29, 2016 Nov 29, 2016
1780 1541: Mitochondrial Complex I inhibition 1545: Decrease in mitochondrial oxidative phosphorylation Dec 19, 2018 Mar 7, 2019 None
1790 1541: Mitochondrial Complex I inhibition 1546: Increased reactive oxygen species (in the mitochondria) Dec 19, 2018 Mar 7, 2019 None
1782 1543: Mitochondrial Complex IV inhibition 1545: Decrease in mitochondrial oxidative phosphorylation Dec 19, 2018 Mar 7, 2019
1785 1543: Mitochondrial Complex IV inhibition 1546: Increased reactive oxygen species (in the mitochondria) Dec 19, 2018 Mar 7, 2019 None
1783 1544: Mitochondrial Complex V inhibition 1545: Decrease in mitochondrial oxidative phosphorylation Dec 19, 2018 Mar 7, 2019
1786 1544: Mitochondrial Complex V inhibition 1546: Increased reactive oxygen species (in the mitochondria) Dec 19, 2018 Dec 19, 2018 None
363 177: Mitochondrial dysfunction 55: Cell injury/death Nov 29, 2016 Nov 29, 2016
582 177: Mitochondrial dysfunction 386: Neuronal network function, Decreased Nov 29, 2016 Dec 3, 2016
660 177: Mitochondrial dysfunction 664: Overwhelmed, Mitochondrial DNA repair mechanisms Nov 29, 2016 Dec 3, 2016
664 177: Mitochondrial dysfunction 583: impaired, Thoracic shivering Nov 29, 2016 Dec 3, 2016 None