Prototypical Stressors

Showing 51 to 75 of 777 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

321	3,5-Dichlorophenol	3,5-Dichlorophenol, CAS-RN: 591-35-5, DTXSID2025006	2 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
466	4-biphenyl carboxylic acid		297: Inhibition of retinaldehyde dehydrogenase leads to population decline
728	4-diethylaminobenzaldehyde (DEAB)		436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
363	4-Hydroxy Nonenal		None
583	4-Hydroxytamoxifen	4-Hydroxytamoxifen, CAS-RN: 68392-35-8, DTXSID3037094	None
515	4-Nitroquinoline 1-oxide		296: Oxidative DNA damage leading to chromosomal aberrations and mutations
77	4-Nonylphenol	4-Nonylphenol, CAS-RN: 104-40-5, DTXSID5033836	None
78	4-propoxyphenol		None
220	5-(N,N-hexamethylene) amiloride (HMA)		None
442	5-Azacytidine	5-Azacytidine, CAS-RN: 320-67-2, DTXSID9020116	8 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2) 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4) 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
126	518-2-5		None
267	5alpha-Dihydrotestosterone	5alpha-Dihydrotestosterone, CAS-RN: 521-18-6, DTXSID9022364	376: Androgen receptor agonism leading to male-biased sex ratio
730	a		None
544	Abamectin	Abamectin, CAS-RN: 71751-41-2, DTXSID8023892	None
656	Acetaldehyde	Acetaldehyde, CAS-RN: 75-07-0, DTXSID5039224	None
57	Acetaminophen	Acetamide, CAS-RN: 60-35-5, DTXSID7020005 Acetaminophen, CAS-RN: 103-90-2, DTXSID2020006 Acetohexamide, CAS-RN: 968-81-0, DTXSID7020007	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
553	acetone	Acetone, CAS-RN: 67-64-1, DTXSID8021482	None
366	Acetyldehyde		None
8	Aceytlsalicylic acid	Aspirin, CAS-RN: 50-78-2, DTXSID5020108	None
319	Acrolein	Acrolein, CAS-RN: 107-02-8, DTXSID5020023	3 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 532: CYP450 upregulation leads to Chronic kidney disease
336	Acrylamide	Acrylamide, CAS-RN: 79-06-1, DTXSID5020027	17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
501	acrylamio		None
364	Acrylonitrile	Acrylonitrile, CAS-RN: 107-13-1, DTXSID5020029	None
324	Adefovir	Adefovir, CAS-RN: 106941-25-7, DTXSID6046214	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
325	Adefovir dipivoxil	Adefovir dipivoxil, CAS-RN: 142340-99-6, DTXSID5046487	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity