Prototypical Stressors

Showing 101 to 125 of 777 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

284	Aristolochic acid	Aristolochic acid, CAS-RN: 313-67-7, DTXSID0040969	397: Bulky DNA adducts leading to mutations
635	Arsenic	Arsenic, CAS-RN: 7440-38-2, DTXSID4023886	3 AOPs 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
430	Arsenite	Arsenite, CAS-RN: 15502-74-6, DTXSID0074007	263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
229	artesunate	Artesunate, CAS-RN: 88495-63-0, DTXSID3042681	144: Endocytic lysosomal uptake leading to liver fibrosis
81	Aryltrifluoroborates		54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
671	Asbestos fibers	Asbestos fibers, CAS-RN: NOCAS, DTXSID0030740	409: Frustrated phagocytosis leads to malignant mesothelioma
534	Ascomycin		154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
156	Aspartame	Aspartame, CAS-RN: 22839-47-0, DTXSID0020107	None
432	Aspirin	Aspirin, CAS-RN: 50-78-2, DTXSID5020108	None
701	Astemizole	Astemizole, CAS-RN: 68844-77-9, DTXSID9020110	None
549	Atorvastatin	Atorvastatin, CAS-RN: 134523-00-5, DTXSID8029868	None
177	atrazine	Atrazine, CAS-RN: 1912-24-9, DTXSID9020112	3 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
425	Aurovertin		None
536	Azathioprine	Azathioprine, CAS-RN: 446-86-6, DTXSID4020119	None
266	B2,4,2',		None
625	bacteria		374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
573	Beclomethasone dipropionate monohydrate	Beclomethasone dipropionate monohydrate, CAS-RN: 77011-63-3, DTXSID00227831	334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
609	Belnacasan (VX-765)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
128	Benomyl	Benomyl, CAS-RN: 17804-35-2, DTXSID5023900	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
420	Benzbromarone	Benzbromarone, CAS-RN: 3562-84-3, DTXSID4022652	None
62	Benzidine	C.I. Azoic Diazo Component 112, CAS-RN: 92-87-5, DTXSID2020137	None
538	Benzo(a)pyrene	Benzo(a)pyrene, CAS-RN: 50-32-8, DTXSID2020139	None
10	Benzo(k)fluoranthene	Benzo(k)fluoranthene, CAS-RN: 207-08-9, DTXSID0023909	None
509	benzo[a]pyrene		310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
165	Benzoic acid, 3-methoxy-2-methyl-, 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide		None