Prototypical Stressors

Showing 176 to 200 of 777 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

478	CHIR98014		None
473	CHIR99021		None
142	Chloroform	Chloroform, CAS-RN: 67-66-3, DTXSID1020306	None
198	chlorophacinone	Chlorophacinone, CAS-RN: 3691-35-8, DTXSID2032348	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
389	Chloroquine bis(phosphate)	Chloroquine bis(phosphate), CAS-RN: 50-63-5, DTXSID7044681	144: Endocytic lysosomal uptake leading to liver fibrosis
117	Chlorpromazine	Chlorpromazine, CAS-RN: 50-53-3, DTXSID0022808	None
280	Chlorpyrifos	Chlorpyrifos, CAS-RN: 2921-88-2, DTXSID4020458	2 AOPs 202: Inhibitor binding to topoisomerase II leading to infant leukaemia 490: Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
766	Chlorpyrifos oxon	Chlorpyrifos oxon, CAS-RN: 5598-15-2, DTXSID1038666	490: Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
356	Chlorzoxazone	Chlorzoxazone, CAS-RN: 95-25-0, DTXSID9022813	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
680	Cholesterol	Cholesterol, CAS-RN: 57-88-5, DTXSID3022401	None
243	Chromafenozide	Chromafenozide, CAS-RN: 143807-66-3, DTXSID4057976	4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
713	Chromium	Chromium, CAS-RN: 7440-47-3, DTXSID3031022	None
326	Cidofovir	Cidofovir, CAS-RN: 113852-37-2, DTXSID3043734	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
645	Cigarette smoke	Cigarette smoke, CAS-RN: NOCAS, DTXSID5035038	4 AOPs 403: combined unhealthy lifestyle factors leading to metabolic syndrome 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
488	cinnamic aldehyde		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
207	ciprofibrate	Ciprofibrate, CAS-RN: 52214-84-3, DTXSID8020331	37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
391	Ciprofloxacin	Ciprofloxacin, CAS-RN: 85721-33-1, DTXSID8022824	144: Endocytic lysosomal uptake leading to liver fibrosis
707	Cisapride	Cisapride, CAS-RN: 81098-60-4, DTXSID3022825	None
716	Cisplatin	Cisplatin, CAS-RN: 15663-27-1, DTXSID4024983	None
406	CITCO	CITCO, CAS-RN: 338404-52-7, DTXSID4040761	None
463	Citral		297: Inhibition of retinaldehyde dehydrogenase leads to population decline
191	Clofibrate	Clofibrate, CAS-RN: 637-07-0, DTXSID3020336	3 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
735	Clomiphene	Clomiphene, CAS-RN: 911-45-5, DTXSID1022843	None
734	Clomiphene citrate (1:1)	Clomiphene citrate (1:1), CAS-RN: 50-41-9, DTXSID8020337	440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
262	Clonixin	Clonixin, CAS-RN: 17737-65-4, DTXSID2046121	152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity