AOP-Wiki

API

All Key Events

Showing 1076 to 1100 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1510	Oxidative Stress in Brain Short Name Oxidative Stress in Brain	0	Molecular	Apr 4, 2018	Apr 4, 2018	4 AOPs 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 501: Excessive iron accumulation leading to neurological disorders 471: Various neuronal effects induced by elavl3, sox10, and mbp
1511	Lipid Peroxidation Short Name Lipid Peroxidation	0	Molecular	Apr 4, 2018	Apr 4, 2018	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
1512	Unfolded Protein Response Short Name Unfolded Protein Response	0	Molecular	Apr 4, 2018	Sep 14, 2023	3 AOPs 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration 285: Inhibition of N-linked glycosylation leads to liver injury 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1513	General Apoptosis Short Name General Apoptosis	1	Cellular	Apr 4, 2018	Oct 18, 2023	3 AOPs 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
1514	Neurodegeneration Short Name Neurodegeneration	0	Organ	Apr 4, 2018	Apr 4, 2018	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
1515	Spermatocyte depletion Short Name Spermatocyte depletion	1	Tissue	May 2, 2018	Jul 28, 2021	212: Histone deacetylase inhibition leading to testicular atrophy
1516	Increase, D1 protein antagonism Short Name Increase, D1 protein antagonism	0	Molecular	May 24, 2018	Oct 7, 2020	None
1517	Decrease, Photosystem II activity Short Name Decrease, PSII activity	0	Molecular	May 24, 2018	Oct 7, 2020	None
1518	Photosynthesis, Decrease Short Name Photosynthesis	0	Cellular	May 24, 2018	May 24, 2018	None
1519	Glycolysis Short Name Glycolysis	0	Cellular	May 24, 2018	May 24, 2018	None
1520	Oxidative phosphorylation Short Name OXPHOS	0	Cellular	May 24, 2018	May 24, 2018	None
1521	Decrease, Growth Short Name Decrease, Growth	1	Individual	May 24, 2018	Jul 6, 2022	12 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 287: Mitochondrial complex III antagonism leading to growth inhibition (2) 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
1522	Inhibition, Chitin synthase 1 Short Name Inhibition, CHS-1	1	Molecular	May 24, 2018	Feb 24, 2021	2 AOPs 342: S-adenosylmethionine depletion leading to population decline (1) 360: Chitin synthase 1 inhibition leading to mortality
1523	Decrease, Cuticular chitin content Short Name Decrease, Cuticular chitin content	1	Tissue	May 24, 2018	Feb 17, 2021	4 AOPs 343: S-adenosylmethionine depletion leading to population decline (2) 342: S-adenosylmethionine depletion leading to population decline (1) 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality
1524	Increase, Premature molting Short Name Increase, Premature molting	1	Individual	May 24, 2018	Feb 17, 2021	6 AOPs 343: S-adenosylmethionine depletion leading to population decline (2) 342: S-adenosylmethionine depletion leading to population decline (1) 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality
1525	Increase, Sulfonylurea receptor binding Short Name Increase, SUR binding	0	Molecular	May 24, 2018	May 24, 2018	2 AOPs 343: S-adenosylmethionine depletion leading to population decline (2) 361: Sulfonylureareceptor binding leading to mortality
1526	Increase, Opening of voltage-dependent calcium channel Short Name	0	Cellular	May 24, 2018	May 24, 2018	2 AOPs 343: S-adenosylmethionine depletion leading to population decline (2) 361: Sulfonylureareceptor binding leading to mortality
1527	Increase, Cell membrane depolarization Short Name Increase, Cell membrane depolarization	0	Cellular	May 24, 2018	May 24, 2018	4 AOPs 343: S-adenosylmethionine depletion leading to population decline (2) 361: Sulfonylureareceptor binding leading to mortality 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
1528	Fatty Acid Beta Oxidation, Decreased Short Name Fatty Acid Beta Oxidation, Decreased	1	Molecular	Jun 11, 2018	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
1529	Blockade, L-Type Calcium Channels Short Name Blockade, L-Type Calcium Channels	0	Molecular	Jun 19, 2018	Nov 1, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1530	Decrease, Calcium currents Short Name Decrease, Calcium currents	0	Cellular	Jun 19, 2018	Jun 19, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1531	Decrease, Calcium binding to Troponin C Short Name Decrease, Calcium binding to Troponin C	0	Cellular	Jun 19, 2018	Jun 19, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1532	Decrease, Cardiac contractility Short Name Decrease, Cardiac contractility	0	Organ	Jun 19, 2018	Jun 19, 2018	3 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
1533	Decrease, Cardiac ejection fraction Short Name Decrease, Cardiac ejection fraction	0	Organ	Jun 19, 2018	Jun 19, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1534	Decrease, Blood pressure Short Name Decrease, Blood pressure	0	Individual	Jun 19, 2018	Jun 19, 2018	None