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Showing 626 to 650 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1760	1530: Decrease, Calcium currents	1536: Disruption, Intracellular calcium mobilization	Jun 21, 2018	Jun 21, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1758	1532: Decrease, Cardiac contractility	1533: Decrease, Cardiac ejection fraction	Jun 19, 2018	Jun 19, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
2824	1532: Decrease, Cardiac contractility	1535: Heart failure	Jan 5, 2023	Jan 5, 2023	None
3176	1532: Decrease, Cardiac contractility	2215: Decrease LV function	Apr 3, 2024	Apr 3, 2024	1 AOP 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
1759	1533: Decrease, Cardiac ejection fraction	1535: Heart failure	Jun 19, 2018	Jun 19, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
2205	1821: Decrease, Cell proliferation	1521: Decrease, Growth	Nov 12, 2020	Jul 6, 2022	4 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
2405	1821: Decrease, Cell proliferation	1878: Decreased, Eye size	May 28, 2021	Aug 7, 2021	1 AOP 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
2724	1821: Decrease, Cell proliferation	2041: Decrease, outgrowth	Jul 28, 2022	May 22, 2023	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
2755	2060: Decrease, Chitin laminar organization	2062: Weak, Procuticle protection	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
1665	1473: Decrease, Chlorophyll synthesis	1474: Decrease, Light harvest capacity	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1347	1266: Decrease, Circulating CCAP	1267: Decrease, Ecdysis motoneuron bursts	Feb 9, 2017	Feb 9, 2017	1 AOP 4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
1000	988: Decrease, Circulating ETH	990: Increase, Incomplete ecdysis	Nov 29, 2016	Dec 3, 2016	None
1008	988: Decrease, Circulating ETH	993: Decrease, Abdominal muscle contraction	Nov 29, 2016	Dec 3, 2016	None
1346	988: Decrease, Circulating ETH	1266: Decrease, Circulating CCAP	Feb 9, 2017	Feb 9, 2017	1 AOP 4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
1600	1446: Decrease, Coupling of OXPHOS	40: Decrease, Mitochondrial ATP production	Jun 29, 2017	Jun 29, 2017	None
2175	1446: Decrease, Coupling of OXPHOS	1808: Decrease, ATP synthase activity	Nov 2, 2020	Nov 2, 2020	None
2182	1446: Decrease, Coupling of OXPHOS	1811: Increase, Complex III dysfunction	Nov 2, 2020	Nov 2, 2020	None
2188	1446: Decrease, Coupling of OXPHOS	1813: Increase, Complex I dysfunction	Nov 2, 2020	Nov 2, 2020	None
2203	1446: Decrease, Coupling of OXPHOS	1771: Decrease, ATP pool	Nov 12, 2020	Jul 6, 2022	3 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
2219	1446: Decrease, Coupling of OXPHOS	1826: Increase, Oxygen consumption	Dec 4, 2020	Dec 4, 2020	None
2763	1446: Decrease, Coupling of OXPHOS	2064: Increase, Cytosolic Ca	Sep 13, 2022	Sep 13, 2022	1 AOP 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
2793	1446: Decrease, Coupling of OXPHOS	2070: Increase, Glycolysis	Nov 1, 2022	Nov 1, 2022	1 AOP 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
2796	1446: Decrease, Coupling of OXPHOS	2072: Increase, Mitochondrial swelling	Nov 1, 2022	Nov 1, 2022	1 AOP 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
1743	1523: Decrease, Cuticular chitin content	1524: Increase, Premature molting	May 24, 2018	Feb 17, 2021	4 AOPs 343: S-adenosylmethionine depletion leading to population decline (2) 342: S-adenosylmethionine depletion leading to population decline (1) 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality
1011	996: Decrease, Digestion of old cuticle	990: Increase, Incomplete ecdysis	Nov 29, 2016	Dec 3, 2016	None

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