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All KERs

Showing 651 to 675 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2171	996: Decrease, Digestion of old cuticle	1524: Increase, Premature molting	Oct 21, 2020	Oct 21, 2020	2 AOPs 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality
1881	1613: Decrease, DHT level	219: Reduction, Plasma 17beta-estradiol concentrations	Apr 18, 2019	Apr 18, 2019	1 AOP 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish
1935	1613: Decrease, DHT level	1614: Decrease, AR activation	Jun 3, 2019	Apr 5, 2024	3 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring
3172	1613: Decrease, DHT level	2213: Impaired, urethral tube closure	Mar 20, 2024	Apr 11, 2024	1 AOP 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
2745	2052: Decrease, dopa decarboxylase	2053: Increase, Defects in tanning of new cuticle	Aug 28, 2022	Aug 28, 2022	1 AOP 466: Doda decarboxylase leading to mortality
1087	1056: Decrease, E2 blood concentrations at hypothalamus	1047: Increased, secretion of GnRH from hypothalamus	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1348	1267: Decrease, Ecdysis motoneuron bursts	1268: Decrease, Excitatory postsynaptic potential	Feb 9, 2017	Feb 9, 2017	1 AOP 4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
3059	2196: Decrease, elavl3	352: N/A, Neurodegeneration	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
1349	1268: Decrease, Excitatory postsynaptic potential	993: Decrease, Abdominal muscle contraction	Feb 9, 2017	Feb 9, 2017	1 AOP 4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
1995	1699: Decease, expression of GnRHR	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Oct 30, 2019	Oct 30, 2019	1 AOP 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
2208	1824: Decrease, FAO	1771: Decrease, ATP pool	Nov 25, 2020	Nov 25, 2020	None
135	328: Decrease, Fecundity	361: Decline, Population	Nov 29, 2016	Dec 3, 2016	None
1886	328: Decrease, Fecundity	360: Decrease, Population growth rate	Apr 22, 2019	Apr 22, 2019	7 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 326: Thermal stress leading to population decline (3) 325: Thermal stress leading to population decline (2) 324: Thermal stress leading to population decline (1) 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2621	328: Decrease, Fecundity	1863: Decrease, Reproduction	Mar 28, 2022	Mar 28, 2022	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2115	1781: Decrease, Fecundity (F3)	360: Decrease, Population growth rate	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
1472	330: Decrease, Fertility	360: Decrease, Population growth rate	Apr 15, 2017	Apr 15, 2017	None
2722	2040: Decrease, GLI1/2 target gene expression	1821: Decrease, Cell proliferation	Jul 28, 2022	Nov 17, 2022	None
2723	2040: Decrease, GLI1/2 target gene expression	1365: Increase, Apoptosis	Jul 28, 2022	Jul 28, 2022	None
2731	2040: Decrease, GLI1/2 target gene expression	2043: Decrease, SHH second messenger production	Aug 23, 2022	May 22, 2023	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
2805	2040: Decrease, GLI1/2 target gene expression	2041: Decrease, outgrowth	Nov 17, 2022	Nov 17, 2022	None
2882	2040: Decrease, GLI1/2 target gene expression	1262: Apoptosis	Apr 6, 2023	May 1, 2023	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
2721	2028: Decrease, GLI1/2 translocation	2040: Decrease, GLI1/2 target gene expression	Jul 28, 2022	Jun 13, 2023	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
2102	1773: Decrease, Global DNA methylation	1774: Increase, Casp transcription	Apr 30, 2020	Apr 30, 2020	2 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2)
2110	1773: Decrease, Global DNA methylation	1778: Decrease, Heritable DNA methylation (F3)	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
2795	2071: Decrease, Glucose pool	1821: Decrease, Cell proliferation	Nov 1, 2022	Nov 1, 2022	1 AOP 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion

Key Event Relationships (KERs)

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