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Showing 426 to 450 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2518	1935: Ang (1-7) levels reduced	1936: Degradation of Ang-II reduced	Oct 28, 2021	Oct 28, 2021	None
2519	1936: Degradation of Ang-II reduced	1741: Induced, Angiotensin (Ang) II accumulation	Oct 28, 2021	Oct 28, 2021	None
2123	26: Antagonism, Androgen receptor	1688: AGD, decreased	May 11, 2020	Aug 7, 2020	1 AOP 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring
2130	26: Antagonism, Androgen receptor	1614: Decrease, AR activation	May 11, 2020	Apr 5, 2024	4 AOPs 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females
2133	26: Antagonism, Androgen receptor	1786: nipple retention, increased	May 11, 2020	Jan 11, 2023	1 AOP 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring
2201	26: Antagonism, Androgen receptor	286: Altered, Transcription of genes by the AR	Nov 2, 2020	Feb 2, 2021	None
129	112: Antagonism, Estrogen receptor	285: Reduction, Vitellogenin synthesis in liver	Nov 29, 2016	Nov 30, 2016	1 AOP 30: Estrogen receptor antagonism leading to reproductive dysfunction
2613	112: Antagonism, Estrogen receptor	1457: EMT	Mar 22, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
3120	112: Antagonism, Estrogen receptor	2207: inhibition, EKR1/2 signaling pathway	Jan 25, 2024	Jan 25, 2024	1 AOP 522: Estrogen antagonism leading to increased risk of autism-like behavior
1061	638: Antagonism, Histamine Receptor (H2)	633: Decrease, histaminergic neuron excitation	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
2720	2027: Antagonism Smoothened	2028: Decrease, GLI1/2 translocation	Jul 28, 2022	Jul 28, 2022	None
2734	2027: Antagonism Smoothened	2044: Decrease, SMO relocation	Aug 23, 2022	May 17, 2023	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
2894	2027: Antagonism Smoothened	2042: OFC	Apr 14, 2023	May 12, 2023	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
1947	1656: TR Antagnoism	756: Hippocampal gene expression, Altered	Jun 8, 2019	Jun 8, 2019	1 AOP 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
1948	1656: TR Antagnoism	402: Cognitive Function, Decreased	Jun 8, 2019	Jun 8, 2019	1 AOP 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
3186	1656: TR Antagnoism	2223: Reduced number of oligodendrocytes	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3193	1656: TR Antagnoism	2107: Hypomyelination	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
1986	1691: Antagonism,LH receptor	1692: Reduction, Progesterone synthesis	Oct 3, 2019	Oct 3, 2019	1 AOP 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1194	1148: Anticoagulant rodenticide interferes with gamma-carboxyglutamate formation, Inhibition of p	1149: Calcium cannot bind to the hydroxyapatite matrix of bone, Osteocalcin and other bone protei	Nov 29, 2016	Dec 3, 2016	None
1368	1262: Apoptosis	1277: Reproductive failure	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1713	1262: Apoptosis	1506: Testicular atrophy	Jan 21, 2018	Jan 21, 2018	None
1735	1262: Apoptosis	1515: Spermatocyte depletion	May 22, 2018	Jul 28, 2021	1 AOP 212: Histone deacetylase inhibition leading to testicular atrophy
1867	1262: Apoptosis	1606: Activation, hepatic stellate cells	Mar 6, 2019	Mar 6, 2019	1 AOP 285: Inhibition of N-linked glycosylation leads to liver injury
1869	1262: Apoptosis	1549: Liver Injury	Mar 6, 2019	Mar 6, 2019	1 AOP 285: Inhibition of N-linked glycosylation leads to liver injury
2191	1262: Apoptosis	1809: Increase, Tissue/organ damage	Nov 2, 2020	Nov 2, 2020	None

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