Key Event Relationships (KERs)

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Showing 851 to 875 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
617 179: Decreased, Mitochondrial fatty acid beta-oxidation 459: Increased, Liver Steatosis Nov 29, 2016 Dec 3, 2016 None
2931 179: Decreased, Mitochondrial fatty acid beta-oxidation 1816: Mitochondrial dysfunction EMPTY May 25, 2023 May 25, 2023 None
3159 179: Decreased, Mitochondrial fatty acid beta-oxidation 177: Mitochondrial dysfunction Mar 13, 2024 Mar 13, 2024
3209 179: Decreased, Mitochondrial fatty acid beta-oxidation 2225: Disrupted Lipid Storage May 8, 2024 May 24, 2024
1535 1404: Decreased, mucosal blood flow 1405: Reduced, mucosal defense Jun 2, 2017 Jun 2, 2017
1538 1406: Decreased, mucous 1405: Reduced, mucosal defense Jun 2, 2017 Jun 2, 2017
634 618: Decreased, Neuronal network function in adult brain 341: Impairment, Learning and memory Nov 29, 2016 Nov 29, 2016
2656 618: Decreased, Neuronal network function in adult brain 1583: Sensory axonal peripheral neuropathy May 16, 2022 May 16, 2022
3072 618: Decreased, Neuronal network function in adult brain 2150: Neurological disorder Oct 17, 2023 Oct 17, 2023
3073 618: Decreased, Neuronal network function in adult brain 188: Neuroinflammation Oct 17, 2023 Oct 17, 2023
3074 618: Decreased, Neuronal network function in adult brain 890: Degeneration of dopaminergic neurons of the nigrostriatal pathway Oct 17, 2023 Oct 17, 2023 None
3076 618: Decreased, Neuronal network function in adult brain 637: impaired, Learning and memory Oct 17, 2023 Oct 17, 2023
1448 1330: Decreased, neuroplasticity 1345: Increased, agitation Apr 14, 2017 Apr 14, 2017
1449 1330: Decreased, neuroplasticity 1346: Increased, depression Apr 14, 2017 Apr 14, 2017
212 193: Decreased, Nitric Oxide 166: Decreased, Long-term potentiation (LTP) Nov 29, 2016 Dec 3, 2016
1084 1045: Decreased, Ovarian E2 1047: Increased, secretion of GnRH from hypothalamus Nov 29, 2016 Dec 3, 2016 None
1085 1045: Decreased, Ovarian E2 1056: Decrease, E2 blood concentrations at hypothalamus Nov 29, 2016 Dec 3, 2016
2803 2074: Decrease overall oxygen binding capacity (methemocyanin formation) 2076: Increase, hemocyanin mRNA Nov 16, 2022 Nov 16, 2022
1433 1324: Decreased, packaged serotonin 1325: Decreased, synaptic release Apr 14, 2017 Apr 14, 2017
503 216: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) 327: Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
881 859: Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids 860: Decreased, Mitochondrial Fatty Acid Beta Oxidation Nov 29, 2016 Nov 29, 2016 None
1491 442: Decreased, Population trajectory 351: Increased Mortality Apr 18, 2017 Apr 18, 2017 None
257 231: Decreased, PPAR-alpha activation 140: Decreased, HSD17B10 expression Nov 29, 2016 Dec 3, 2016
2042 231: Decreased, PPAR-alpha activation 459: Increased, Liver Steatosis Feb 22, 2020 Feb 22, 2020 None
259 232: Decreased, PPAR-beta activation 140: Decreased, HSD17B10 expression Nov 29, 2016 Dec 3, 2016