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Showing 951 to 975 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2815	1686: Energy Deposition	2083: Cataracts	Dec 18, 2022	Mar 11, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
2832	1686: Energy Deposition	1492: Tissue resident cell activation	Jan 25, 2023	Mar 21, 2023	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2837	1686: Energy Deposition	2098: Abnormal Neural Remodeling	Jan 25, 2023	Feb 14, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2838	1686: Energy Deposition	341: Impairment, Learning and memory	Jan 25, 2023	Mar 21, 2023	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2847	1686: Energy Deposition	2089: Altered Bone Cell Homeostasis	Jan 25, 2023	Mar 22, 2023	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2848	1686: Energy Deposition	2090: Bone Remodeling	Jan 25, 2023	Mar 22, 2023	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2849	1686: Energy Deposition	2091: Bone Loss	Jan 25, 2023	Mar 22, 2023	1 AOP 482: Deposition of energy leading to occurrence of bone loss
1798	1550: Ionizing Energy	1553: Increase mutations	Dec 19, 2018	Dec 19, 2018	None
1799	1550: Ionizing Energy	1554: Increase chromosomal aberrations	Dec 19, 2018	Dec 19, 2018	None
2379	1550: Ionizing Energy	1115: Increased, Reactive oxygen species	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2380	1550: Ionizing Energy	1194: Increase, DNA Damage	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2390	1550: Ionizing Energy	1088: Increased, Oxidative Stress	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2392	1550: Ionizing Energy	752: Altered, Meiotic chromosome dynamics	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2393	1550: Ionizing Energy	1798: Decreased spermatogenesis	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2394	1550: Ionizing Energy	406: impaired, Fertility	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2395	1550: Ionizing Energy	1696: Decrease of egg production and cummulative fecundity	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2396	1550: Ionizing Energy	997: Decreased, Population size	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2397	1550: Ionizing Energy	1775: Increase, Oocyte apoptosis	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2921	2138: Derease, testosterone levels	219: Reduction, Plasma 17beta-estradiol concentrations	May 22, 2023	May 22, 2023	None
2925	2138: Derease, testosterone levels	2139: Reduction, the ratio of E2/11-KT in plasma	May 22, 2023	May 22, 2023	None
659	663: Desensitization, Nicotinic acetylcholine receptor	386: Neuronal network function, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
1309	663: Desensitization, Nicotinic acetylcholine receptor	1243: Altered, Ca2+-calmodulin activated signal transduction	Nov 29, 2016	Dec 3, 2016	2 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
1356	1272: Differentiation of Myofibroblast	1274: Production of α-smooth muscle actin	Feb 15, 2017	Feb 15, 2017	None
973	944: dimerization, AHR/ARNT	945: reduced dimerization, ARNT/HIF1-alpha	Nov 29, 2016	Mar 23, 2018	2 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 151: AhR activation leading to preeclampsia
1350	944: dimerization, AHR/ARNT	1269: Increase, COX-2 expression	Feb 9, 2017	May 9, 2017	1 AOP 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2

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