Key Event Relationships (KERs)

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Showing 1526 to 1550 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2826 1364: Increase, ROS 1392: Oxidative Stress Jan 9, 2023 Jan 9, 2023
282 257: Increase, ROS production 193: Decreased, Nitric Oxide Nov 29, 2016 Dec 3, 2016
283 257: Increase, ROS production 356: Increased, Oxidative damage Nov 29, 2016 Dec 3, 2016
912 257: Increase, ROS production 177: Mitochondrial dysfunction Nov 29, 2016 Dec 3, 2016 None
1602 257: Increase, ROS production 1194: Increase, DNA Damage Jun 29, 2017 Jun 29, 2017 None
1603 257: Increase, ROS production 1445: Increased, LPO Jun 29, 2017 Jun 29, 2017
1623 257: Increase, ROS production 1032: Increased, secretion of local growth factors Jul 26, 2017 Jul 26, 2017 None
1754 257: Increase, ROS production 1446: Decrease, Coupling of OXPHOS Jun 12, 2018 Jun 12, 2018 None
2089 257: Increase, ROS production 1767: Increase, Protein oxidation Apr 30, 2020 Apr 30, 2020
2093 257: Increase, ROS production 1770: Decrease, MMP Apr 30, 2020 Apr 30, 2020
2099 257: Increase, ROS production 1608: Increase,Oxidative DNA damage Apr 30, 2020 Apr 30, 2020
2187 257: Increase, ROS production 1365: Increase, Apoptosis Nov 2, 2020 Nov 2, 2020 None
2225 257: Increase, ROS production 1827: Increase, Global methylation Dec 4, 2020 Dec 4, 2020
2305 257: Increase, ROS production 202: Inhibition, Nuclear factor kappa B (NF-kB) Mar 30, 2021 Mar 30, 2021 None
2308 257: Increase, ROS production 1172: Increased activation, Nuclear factor kappa B (NF-kB) Mar 30, 2021 Mar 30, 2021 None
2348 257: Increase, ROS production 1861: D1 protein deactivation Apr 11, 2021 Apr 11, 2021 None
2590 257: Increase, ROS production 1634: Increase, Oxidative DNA damage Mar 1, 2022 Mar 1, 2022
2998 257: Increase, ROS production 1969: Increase, Oxidative Stress Aug 21, 2023 Aug 21, 2023
779 778: Increase, Regenerative cell proliferation (corneal cells) 779: Increase, Papillomas/carcinomas (squamous cells) Nov 29, 2016 Dec 3, 2016
782 781: Increase, Regenerative cell proliferation (forestomach epithelial cells) 782: Increase, Hyperplasia (forestomach epithelial cells) Nov 29, 2016 Dec 3, 2016
789 787: Increase, Regenerative cell proliferation (hepatocytes) 774: Increase, Preneoplastic foci (hepatocytes) Nov 29, 2016 Dec 3, 2016
727 734: Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) 735: Increase, Hyperplasia (terminal bronchiolar cells) Nov 29, 2016 Dec 3, 2016
760 710: Increase, Regenerative cell proliferation (tubular epithelial cells) 767: Increase, Hyperplasia (renal tubular cells) Nov 29, 2016 Dec 3, 2016
785 710: Increase, Regenerative cell proliferation (tubular epithelial cells) 784: Increase, Hyperplasia (tubular epithelial cells) Nov 29, 2016 Dec 3, 2016
797 795: Increase, Regenerative cell proliferation (urothelial cells) 796: Increase, Hyperplasia (urothelial) Nov 29, 2016 Dec 3, 2016