Key Event Relationships (KERs)

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Showing 2101 to 2125 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2636 105: Inhibition, ETC complexes of the respiratory chain 1770: Decrease, MMP Apr 8, 2022 Apr 8, 2022
2821 105: Inhibition, ETC complexes of the respiratory chain 177: Mitochondrial dysfunction Jan 5, 2023 Jan 5, 2023
475 451: Inhibition, Mitochondrial fatty acid beta-oxidation 327: Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
538 451: Inhibition, Mitochondrial fatty acid beta-oxidation 459: Increased, Liver Steatosis Nov 29, 2016 Dec 3, 2016
1049 1013: Inhibition, Motor neuron activity 1014: Induction, Somatic muscle paralysis Nov 29, 2016 Dec 3, 2016 None
442 424: Inhibition, Na+/I- symporter (NIS) 425: Thyroidal Iodide, Decreased Nov 29, 2016 May 29, 2018
552 424: Inhibition, Na+/I- symporter (NIS) 277: TH synthesis, Decreased Nov 29, 2016 Dec 3, 2016
1503 424: Inhibition, Na+/I- symporter (NIS) 341: Impairment, Learning and memory May 10, 2017 Apr 4, 2019
2232 424: Inhibition, Na+/I- symporter (NIS) 281: T4 in serum, Decreased Dec 9, 2020 Dec 9, 2020
934 887: Inhibition, NADH-ubiquinone oxidoreductase (complex I) 177: Mitochondrial dysfunction Nov 29, 2016 Aug 25, 2017
1809 887: Inhibition, NADH-ubiquinone oxidoreductase (complex I) 1477: Decrease, OXPHOS Dec 20, 2018 Dec 20, 2018
1940 887: Inhibition, NADH-ubiquinone oxidoreductase (complex I) 1545: Decrease in mitochondrial oxidative phosphorylation Jun 7, 2019 Jun 7, 2019
3241 2233: Inhibition, NFAT 2231: Increased, activation of RAAS Jun 7, 2024 Jun 7, 2024 None
3242 2233: Inhibition, NFAT 2232: Inhibition, COX-2 activity Jun 7, 2024 Jun 7, 2024 None
213 195: Inhibition, NMDARs 52: Decreased, Calcium influx Nov 29, 2016 Apr 7, 2018
214 195: Inhibition, NMDARs 341: Impairment, Learning and memory Nov 29, 2016 Dec 3, 2016 None
215 195: Inhibition, NMDARs 191: Neuronal dysfunction Nov 29, 2016 Dec 3, 2016 None
3124 195: Inhibition, NMDARs 2208: Aberrant, synaptic formation and plasticity Jan 25, 2024 Jan 25, 2024
387 202: Inhibition, Nuclear factor kappa B (NF-kB) 152: Suppression, Inflammatory cytokines Nov 29, 2016 Dec 3, 2016
1828 202: Inhibition, Nuclear factor kappa B (NF-kB) 1575: Activation, Caspase 8 pathway Jan 7, 2019 Mar 7, 2019
1871 202: Inhibition, Nuclear factor kappa B (NF-kB) 986: Impairment of TDAR Mar 12, 2019 Mar 12, 2019 None
1921 202: Inhibition, Nuclear factor kappa B (NF-kB) 1569: Impaired T cell activation May 23, 2019 Jun 25, 2019 None
2003 202: Inhibition, Nuclear factor kappa B (NF-kB) 1702: Suppression of T cell activation Nov 17, 2019 Mar 2, 2023
2306 202: Inhibition, Nuclear factor kappa B (NF-kB) 1496: Increased proinflammatory mediators Mar 30, 2021 Mar 30, 2021 None
2644 202: Inhibition, Nuclear factor kappa B (NF-kB) 1633: Increase in inflammation Apr 8, 2022 Apr 8, 2022