Prototypical Stressors

Showing 351 to 375 of 777 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

178	Haloperidol	Haloperidol, CAS-RN: 52-86-8, DTXSID4034150	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
351	Halothane	Halothane, CAS-RN: 151-67-7, DTXSID4025371	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
620	HCoV-NL63		2 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
675	Heavy metals (cadmium, lead, copper, iron, nickel)		3 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 521: Essential element imbalance leads to reproductive failure via oxidative stress
276	Helicobacter pylori		217: Gastric ulcer formation
299	Helicobacter pylori infection		229: Helicobacter pylori to gastric ulcer
344	Heptachlor	Heptachlor, CAS-RN: 76-44-8, DTXSID3020679	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
150	Hexachlorobenzene	Hexachlorobenzene, CAS-RN: 118-74-1, DTXSID2020682	131: Aryl hydrocarbon receptor activation leading to uroporphyria
500	High aspect ratio material		2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
646	high fat diet		403: combined unhealthy lifestyle factors leading to metabolic syndrome
503	High LET Ra		None
504	High LET Radiation		None
610	HMR3480		None
623	Hy		None
446	Hydralazine hydrochloride	Hydralazine hydrochloride, CAS-RN: 304-20-1, DTXSID1044645	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
132	Hydrocarbons, various		None
454	Hydrogen peroxide	Hydrogen peroxide, CAS-RN: 7722-84-1, DTXSID2020715	296: Oxidative DNA damage leading to chromosomal aberrations and mutations
514	Hydroquinone	Hydroquinone, CAS-RN: 123-31-9, DTXSID7020716	296: Oxidative DNA damage leading to chromosomal aberrations and mutations
82	Ibuprofen	Ibuprofen, CAS-RN: 15687-27-1, DTXSID5020732	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
777	Ifosfamide	Ifosfamide, CAS-RN: 3778-73-2, DTXSID7020760	532: CYP450 upregulation leads to Chronic kidney disease
614	iguratimod	Iguratimod, CAS-RN: 123663-49-0, DTXSID0048971	277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
489	IL-1 receptor antagonist（IL-1Ra）(Anakinra)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
438	IL-1 receptor antagonist（IL-1Ra）(Anakinra), anti-IL-1b antibody (Canakinumab), soluble IL-1R (Rilonacept)		None
519	Imiquimod	Imiquimod, CAS-RN: 99011-02-6, DTXSID7041047	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
119	Immepip		None